ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Cytochrome c oxidase subunit 6B1

Intermolecular
Cysteine 40 and cysteine 40
Intramolecular
Cysteine 40 and cysteine 54 L
Cysteine 30 and cysteine 65 L
A redox-regulated disulphide may form between two units of Cytochrome c oxidase subunit 6B1 at cysteines 40 and 40 (39 and 39 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3ag1
Structure name
bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at 280 k
Structure deposition date
2010-03-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide A name
Cytochrome c oxidase subunit 6B1
Peptide B name
Cytochrome c oxidase subunit 6B1
Peptide A accession
P00429
Peptide B accession
P00429
Peptide A residue number
40
Peptide B residue number
40

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase subunit 6B1 between cysteines 40 and 54 (39 and 53 respectively in this structure).

Details

Redox score ?
85
PDB code
7o3e
Structure name
murine supercomplex ciii2civ in the intermediate locked conformation
Structure deposition date
2021-04-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56391
Residue number A
40
Residue number B
54
Peptide name
Cytochrome c oxidase subunit 6B1

Ligandability

Cysteine 40 of Cytochrome c oxidase subunit 6B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Cytochrome c oxidase subunit 6B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase subunit 6B1 between cysteines 30 and 65 (29 and 64 respectively in this structure).

Details

Redox score ?
79
PDB code
2eim
Structure name
zinc ion binding structure of bovine heart cytochrome c oxidase in the fully reduced state
Structure deposition date
2007-03-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00429
Residue number A
30
Residue number B
65
Peptide name
Cytochrome c oxidase subunit 6B1

Ligandability

Cysteine 30 of Cytochrome c oxidase subunit 6B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Cytochrome c oxidase subunit 6B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: