ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gamma-aminobutyric acid receptor subunit alpha-1

Intramolecular
Cysteine 165 and cysteine 179
Cysteine 260 and cysteine 319
A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit alpha-1 between cysteines 165 and 179 (138 and 152 respectively in this structure).

Details

Redox score ?
82
PDB code
6dw0
Structure name
cryo-em structure of the benzodiazepine-sensitive alpha1beta1gamma2s tri-heteromeric gabaa receptor in complex with gaba (whole map)
Structure deposition date
2018-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P62813
Residue number A
165
Residue number B
179
Peptide name
Gamma-aminobutyric acid receptor subunit alpha-1

Ligandability

Cysteine 165 of Gamma-aminobutyric acid receptor subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Gamma-aminobutyric acid receptor subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit alpha-1 between cysteines 260 and 319 (233 and 292 respectively in this structure).

Details

Redox score ?
77
PDB code
6dw0
Structure name
cryo-em structure of the benzodiazepine-sensitive alpha1beta1gamma2s tri-heteromeric gabaa receptor in complex with gaba (whole map)
Structure deposition date
2018-06-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
24
Peptide accession
P62813
Residue number A
260
Residue number B
319
Peptide name
Gamma-aminobutyric acid receptor subunit alpha-1

Ligandability

Cysteine 260 of Gamma-aminobutyric acid receptor subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Gamma-aminobutyric acid receptor subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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