a tool for identifying drug-targetable redox-active disulphides

Carboxypeptidase A1

Intramolecular

Cysteine 248 and cysteine 271

A redox-regulated disulphide may form within Carboxypeptidase A1 between cysteines 248 and 271 (138 and 161 respectively in this structure).

Details

Redox score ?

84

PDB code

Structure name

crystal structure of human carboxypeptidase a1

Structure deposition date

2007-07-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

45

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

248

Residue number B

271

Peptide name

Carboxypeptidase A1

Ligandability

Cysteine 248 of Carboxypeptidase A1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Carboxypeptidase A1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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