ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glutamine synthetase

Intermolecular
Cysteine 163 and cysteine 42
Intramolecular
Cysteine 252 and cysteine 346
A redox-regulated disulphide may form between two units of Glutamine synthetase at cysteines 163 and 42. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2qc8
Structure name
crystal structure of human glutamine synthetase in complex with adp and methionine sulfoximine phosphate
Structure deposition date
2007-06-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide A name
Glutamine synthetase
Peptide B name
Glutamine synthetase
Peptide A accession
P15104
Peptide B accession
P15104
Peptide A residue number
163
Peptide B residue number
42

Ligandability

Cysteine 163 of Glutamine synthetase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 42 of Glutamine synthetase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamine synthetase between cysteines 252 and 346.

Details

Redox score ?
71
PDB code
2uu7
Structure name
crystal structure of apo glutamine synthetase from dog ( canis familiaris)
Structure deposition date
2007-02-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
8
% buried
100
Peptide accession
Q8HZM5
Residue number A
252
Residue number B
346
Peptide name
Glutamine synthetase

Ligandability

Cysteine 252 of Glutamine synthetase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 346 of Glutamine synthetase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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