ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Aminopeptidase N

Intramolecular
Cysteine 761 and cysteine 768
Cysteine 798 and cysteine 834
Cysteine 761 and cysteine 798
A redox-regulated disulphide may form within Aminopeptidase N between cysteines 761 and 768.

Details

Redox score ?
83
PDB code
5lhd
Structure name
structure of glycosylated human aminopeptidase n
Structure deposition date
2016-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15144
Residue number A
761
Residue number B
768
Peptide name
Aminopeptidase N

Ligandability

Cysteine 761 of Aminopeptidase N

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 768 of Aminopeptidase N

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aminopeptidase N between cysteines 798 and 834.

Details

Redox score ?
76
PDB code
7vpq
Structure name
structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans
Structure deposition date
2021-10-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15144
Residue number A
798
Residue number B
834
Peptide name
Aminopeptidase N

Ligandability

Cysteine 798 of Aminopeptidase N

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 834 of Aminopeptidase N

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aminopeptidase N between cysteines 761 and 798. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6atk
Structure name
crystal structure of the human coronavirus 229e spike protein receptor binding domain in complex with human aminopeptidase n
Structure deposition date
2017-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15144
Residue number A
761
Residue number B
798
Peptide name
Aminopeptidase N

Ligandability

Cysteine 761 of Aminopeptidase N

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 798 of Aminopeptidase N

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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