ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Poliovirus receptor

Intramolecular
Cysteine 266 and cysteine 312
Cysteine 166 and cysteine 221
Cysteine 49 and cysteine 123
A redox-regulated disulphide may form within Poliovirus receptor between cysteines 266 and 312.

Details

Redox score ?
84
PDB code
6o3o
Structure name
structure of human dnam-1 (cd226) bound to nectin-like protein-5 (necl-5)
Structure deposition date
2019-02-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15151
Residue number A
266
Residue number B
312
Peptide name
Poliovirus receptor

Ligandability

Cysteine 266 of Poliovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Poliovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poliovirus receptor between cysteines 166 and 221.

Details

Redox score ?
81
PDB code
6arq
Structure name
crystal structure of cd96 (d1) bound to cd155/necl-5 (d1-3)
Structure deposition date
2017-08-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15151
Residue number A
166
Residue number B
221
Peptide name
Poliovirus receptor

Ligandability

Cysteine 166 of Poliovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Poliovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poliovirus receptor between cysteines 49 and 123.

Details

Redox score ?
80
PDB code
6o3o
Structure name
structure of human dnam-1 (cd226) bound to nectin-like protein-5 (necl-5)
Structure deposition date
2019-02-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15151
Residue number A
49
Residue number B
123
Peptide name
Poliovirus receptor

Ligandability

Cysteine 49 of Poliovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Poliovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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