ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon gamma receptor 1

Intramolecular
Cysteine 195 and cysteine 200
Cysteine 122 and cysteine 167
Cysteine 77 and cysteine 85
Cysteine 214 and cysteine 235
A redox-regulated disulphide may form within Interferon gamma receptor 1 between cysteines 195 and 200 (178 and 183 respectively in this structure).

Details

Redox score ?
88
PDB code
1fg9
Structure name
3:1 complex of interferon-gamma receptor with interferon- gamma dimer
Structure deposition date
2000-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15260
Residue number A
195
Residue number B
200
Peptide name
Interferon gamma receptor 1

Ligandability

Cysteine 195 of Interferon gamma receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Interferon gamma receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon gamma receptor 1 between cysteines 122 and 167 (105 and 150 respectively in this structure).

Details

Redox score ?
83
PDB code
6e3l
Structure name
interferon gamma signalling complex with ifngr1 and ifngr2
Structure deposition date
2018-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15260
Residue number A
122
Residue number B
167
Peptide name
Interferon gamma receptor 1

Ligandability

Cysteine 122 of Interferon gamma receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of Interferon gamma receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon gamma receptor 1 between cysteines 77 and 85 (60 and 68 respectively in this structure).

Details

Redox score ?
81
PDB code
1fyh
Structure name
1:1 complex between an interferon gamma single-chain variant and its receptor
Structure deposition date
2000-09-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
48
Peptide accession
P15260
Residue number A
77
Residue number B
85
Peptide name
Interferon gamma receptor 1

Ligandability

Cysteine 77 of Interferon gamma receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of Interferon gamma receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon gamma receptor 1 between cysteines 214 and 235 (197 and 218 respectively in this structure).

Details

Redox score ?
78
PDB code
1fg9
Structure name
3:1 complex of interferon-gamma receptor with interferon- gamma dimer
Structure deposition date
2000-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15260
Residue number A
214
Residue number B
235
Peptide name
Interferon gamma receptor 1

Ligandability

Cysteine 214 of Interferon gamma receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 235 of Interferon gamma receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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