ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta-1,4-galactosyltransferase 1

Intramolecular
Cysteine 130 and cysteine 172
Cysteine 243 and cysteine 262
A redox-regulated disulphide may form within Beta-1,4-galactosyltransferase 1 between cysteines 130 and 172.

Details

Redox score ?
88
PDB code
2aes
Structure name
crystal structure of human m340h-beta1,4-galactosyltransferase-i (m340h-b4gal-t1) in complex with glcnac-beta1,2-man-alpha1,3-man- beta-or
Structure deposition date
2005-07-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15291
Residue number A
130
Residue number B
172
Peptide name
Beta-1,4-galactosyltransferase 1

Ligandability

Cysteine 130 of Beta-1,4-galactosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of Beta-1,4-galactosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-1,4-galactosyltransferase 1 between cysteines 243 and 262.

Details

Redox score ?
82
PDB code
2ae7
Structure name
crystal structure of human m340h-beta1,4-galactosyltransferase-i (m340h-b4gal-t1) in complex with pentasaccharide
Structure deposition date
2005-07-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15291
Residue number A
243
Residue number B
262
Peptide name
Beta-1,4-galactosyltransferase 1

Ligandability

Cysteine 243 of Beta-1,4-galactosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of Beta-1,4-galactosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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