ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Prostatic acid phosphatase

Intramolecular
Cysteine 161 and cysteine 372
Cysteine 347 and cysteine 351
A redox-regulated disulphide may form within Prostatic acid phosphatase between cysteines 161 and 372 (2129 and 2340 respectively in this structure).

Details

Redox score ?
89
PDB code
1cvi
Structure name
crystal structure of human prostatic acid phosphatase
Structure deposition date
1999-08-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15309
Residue number A
161
Residue number B
372
Peptide name
Prostatic acid phosphatase

Ligandability

Cysteine 161 of Prostatic acid phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of Prostatic acid phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prostatic acid phosphatase between cysteines 347 and 351 (3314 and 3318 respectively in this structure).

Details

Redox score ?
86
PDB code
1nd6
Structure name
crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design
Structure deposition date
2002-12-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15309
Residue number A
347
Residue number B
351
Peptide name
Prostatic acid phosphatase

Ligandability

Cysteine 347 of Prostatic acid phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 351 of Prostatic acid phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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