ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Proto-oncogene vav

Intramolecular
Cysteine 546 and cysteine 564
Cysteine 529 and cysteine 532
Cysteine 529 and cysteine 557
Cysteine 546 and cysteine 549
Cysteine 549 and cysteine 564
Cysteine 532 and cysteine 557
Cysteine 196 and cysteine 197
Cysteine 82 and cysteine 83
Cysteine 196 and cysteine 198
Cysteine 197 and cysteine 198
More...
Cysteine 7 and cysteine 14
Cysteine 44 and cysteine 82
Cysteine 284 and cysteine 369
A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 546 and 564.

Details

Redox score ?
90
PDB code
6new
Structure name
apo structure of the activated truncation of vav1
Structure deposition date
2018-12-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
5
% buried
8
Peptide accession
P15498
Residue number A
546
Residue number B
564
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 546 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 564 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 529 and 532.

Details

Redox score ?
90
PDB code
3bji
Structure name
structural basis of promiscuous guanine nucleotide exchange by the t-cell essential vav1
Structure deposition date
2007-12-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
4
% buried
32
Peptide accession
P15498
Residue number A
529
Residue number B
532
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 529 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 532 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 529 and 557.

Details

Redox score ?
88
PDB code
3bji
Structure name
structural basis of promiscuous guanine nucleotide exchange by the t-cell essential vav1
Structure deposition date
2007-12-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
57
Minimum pKa ?
5
% buried
36
Peptide accession
P15498
Residue number A
529
Residue number B
557
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 529 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 557 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 546 and 549.

Details

Redox score ?
87
PDB code
3bji
Structure name
structural basis of promiscuous guanine nucleotide exchange by the t-cell essential vav1
Structure deposition date
2007-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
8
Peptide accession
P15498
Residue number A
546
Residue number B
549
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 546 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 549 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 549 and 564.

Details

Redox score ?
81
PDB code
6new
Structure name
apo structure of the activated truncation of vav1
Structure deposition date
2018-12-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
6
Peptide accession
P15498
Residue number A
549
Residue number B
564
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 549 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 564 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 532 and 557.

Details

Redox score ?
76
PDB code
6new
Structure name
apo structure of the activated truncation of vav1
Structure deposition date
2018-12-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
26
Peptide accession
P15498
Residue number A
532
Residue number B
557
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 532 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 557 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 196 and 197. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2vrw
Structure name
critical structural role for the ph and c1 domains of the vav1 exchange factor
Structure deposition date
2008-04-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
6
Peptide accession
P27870
Residue number A
196
Residue number B
197
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 196 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 82 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3ky9
Structure name
autoinhibited vav1
Structure deposition date
2009-12-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
46
Peptide accession
P15498
Residue number A
82
Residue number B
83
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 82 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 196 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6nf1
Structure name
vav1 inhibited by an allosteric inhibitor: vav1 inhibitors block gef activity
Structure deposition date
2018-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
21
Peptide accession
P15498
Residue number A
196
Residue number B
198
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 196 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 197 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3bji
Structure name
structural basis of promiscuous guanine nucleotide exchange by the t-cell essential vav1
Structure deposition date
2007-12-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
47
Peptide accession
P15498
Residue number A
197
Residue number B
198
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 197 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 7 and 14. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3ky9
Structure name
autoinhibited vav1
Structure deposition date
2009-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
85
Peptide accession
P15498
Residue number A
7
Residue number B
14
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 7 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 14 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 44 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6nf1
Structure name
vav1 inhibited by an allosteric inhibitor: vav1 inhibitors block gef activity
Structure deposition date
2018-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
91
Peptide accession
P15498
Residue number A
44
Residue number B
82
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 44 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene vav between cysteines 284 and 369. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6nf1
Structure name
vav1 inhibited by an allosteric inhibitor: vav1 inhibitors block gef activity
Structure deposition date
2018-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
94
Peptide accession
P15498
Residue number A
284
Residue number B
369
Peptide name
Proto-oncogene vav

Ligandability

Cysteine 284 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 369 of Proto-oncogene vav

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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