ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Intramolecular
Cysteine 51 and cysteine 79
Cysteine 60 and cysteine 81
Cysteine 126 and cysteine 136
Cysteine 228 and cysteine 233
Cysteine 165 and cysteine 178
Cysteine 136 and cysteine 165
Cysteine 136 and cysteine 178
Cysteine 126 and cysteine 165
Cysteine 126 and cysteine 178
Cysteine 79 and cysteine 81
A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 51 and 79 (32 and 60 respectively in this structure).

Details

Redox score ?
84
PDB code
4rs1
Structure name
crystal structure of receptor-cytokine complex
Structure deposition date
2014-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15509
Residue number A
51
Residue number B
79
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 51 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 60 and 81 (41 and 62 respectively in this structure).

Details

Redox score ?
83
PDB code
4rs1
Structure name
crystal structure of receptor-cytokine complex
Structure deposition date
2014-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15509
Residue number A
60
Residue number B
81
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 60 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 126 and 136 (107 and 117 respectively in this structure).

Details

Redox score ?
83
PDB code
4nkq
Structure name
structure of a cytokine receptor complex
Structure deposition date
2013-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15509
Residue number A
126
Residue number B
136
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 126 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 228 and 233 (209 and 214 respectively in this structure).

Details

Redox score ?
82
PDB code
4nkq
Structure name
structure of a cytokine receptor complex
Structure deposition date
2013-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
28
Peptide accession
P15509
Residue number A
228
Residue number B
233
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 228 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 165 and 178 (146 and 159 respectively in this structure).

Details

Redox score ?
82
PDB code
4nkq
Structure name
structure of a cytokine receptor complex
Structure deposition date
2013-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
30
Peptide accession
P15509
Residue number A
165
Residue number B
178
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 165 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 136 and 165 (117 and 146 respectively in this structure).

Details

Redox score ?
60
PDB code
4nkq
Structure name
structure of a cytokine receptor complex
Structure deposition date
2013-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
nan
Peptide accession
P15509
Residue number A
136
Residue number B
165
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 136 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 136 and 178 (117 and 159 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
4rs1
Structure name
crystal structure of receptor-cytokine complex
Structure deposition date
2014-11-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15509
Residue number A
136
Residue number B
178
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 136 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 126 and 165 (107 and 146 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
4nkq
Structure name
structure of a cytokine receptor complex
Structure deposition date
2013-11-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
nan
Peptide accession
P15509
Residue number A
126
Residue number B
165
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 126 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 126 and 178 (107 and 159 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4rs1
Structure name
crystal structure of receptor-cytokine complex
Structure deposition date
2014-11-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15509
Residue number A
126
Residue number B
178
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 126 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor receptor subunit alpha between cysteines 79 and 81 (60 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4rs1
Structure name
crystal structure of receptor-cytokine complex
Structure deposition date
2014-11-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15509
Residue number A
79
Residue number B
81
Peptide name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Ligandability

Cysteine 79 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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