Membrane cofactor protein
Intermolecular
Cysteine 64 and cysteine 64
Intramolecular
Cysteine 35 and cysteine 80
Cysteine 162 and cysteine 80
Cysteine 127 and cysteine 157
Cysteine 256 and cysteine 283
Cysteine 99 and cysteine 141
Cysteine 228 and cysteine 270
Cysteine 162 and cysteine 210
Cysteine 191 and cysteine 223
Cysteine 64 and cysteine 94
1ckl C 30 D 30
A redox-regulated disulphide may form between two units of Membrane cofactor protein at cysteines 64 and 64 (30 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
1ckl
Structure name
n-terminal two domains of human cd46 (membrane cofactor protein, mcp)
Structure deposition date
1999-04-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Membrane cofactor protein
Peptide B name
Membrane cofactor protein
Peptide A accession
P15529
Peptide B accession
P15529
Peptide A residue number
64
Peptide B residue number
64
Ligandability
3o8e D 1 D 46
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 35 and 80 (1 and 46 respectively in this structure).
Details
Redox score ?
90
PDB code
3o8e
Structure name
structure of extracelllar portion of cd46 in complex with adenovirus type 11 knob
Structure deposition date
2010-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
35
Residue number B
80
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 35 of Membrane cofactor protein
Cysteine 80 of Membrane cofactor protein
3l89 V 1 V 46
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 162 and 80 (1 and 46 respectively in this structure).
Details
Redox score ?
89
PDB code
3l89
Structure name
human adenovirus type 21 knob in complex with domains scr1 and scr2 of cd46 (membrane cofactor protein, mcp)
Structure deposition date
2009-12-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
162
Residue number B
80
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 162 of Membrane cofactor protein
Cysteine 80 of Membrane cofactor protein
1ckl E 93 E 123
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 127 and 157 (93 and 123 respectively in this structure).
Details
Redox score ?
88
PDB code
1ckl
Structure name
n-terminal two domains of human cd46 (membrane cofactor protein, mcp)
Structure deposition date
1999-04-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
127
Residue number B
157
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 127 of Membrane cofactor protein
Cysteine 157 of Membrane cofactor protein
3o8e B 222 B 249
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 256 and 283 (222 and 249 respectively in this structure).
Details
Redox score ?
88
PDB code
3o8e
Structure name
structure of extracelllar portion of cd46 in complex with adenovirus type 11 knob
Structure deposition date
2010-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
256
Residue number B
283
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 256 of Membrane cofactor protein
Cysteine 283 of Membrane cofactor protein
3l89 R 65 R 107
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 99 and 141 (65 and 107 respectively in this structure).
Details
Redox score ?
86
PDB code
3l89
Structure name
human adenovirus type 21 knob in complex with domains scr1 and scr2 of cd46 (membrane cofactor protein, mcp)
Structure deposition date
2009-12-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
99
Residue number B
141
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 99 of Membrane cofactor protein
Cysteine 141 of Membrane cofactor protein
3o8e B 194 B 236
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 228 and 270 (194 and 236 respectively in this structure).
Details
Redox score ?
86
PDB code
3o8e
Structure name
structure of extracelllar portion of cd46 in complex with adenovirus type 11 knob
Structure deposition date
2010-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
228
Residue number B
270
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 228 of Membrane cofactor protein
Cysteine 270 of Membrane cofactor protein
3o8e D 128 D 176
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 162 and 210 (128 and 176 respectively in this structure).
Details
Redox score ?
86
PDB code
3o8e
Structure name
structure of extracelllar portion of cd46 in complex with adenovirus type 11 knob
Structure deposition date
2010-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
162
Residue number B
210
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 162 of Membrane cofactor protein
Cysteine 210 of Membrane cofactor protein
3o8e B 157 B 189
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 191 and 223 (157 and 189 respectively in this structure).
Details
Redox score ?
86
PDB code
3o8e
Structure name
structure of extracelllar portion of cd46 in complex with adenovirus type 11 knob
Structure deposition date
2010-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
191
Residue number B
223
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 191 of Membrane cofactor protein
Cysteine 223 of Membrane cofactor protein
3l89 V 30 V 60
A redox-regulated disulphide may form within Membrane cofactor protein between cysteines 64 and 94 (30 and 60 respectively in this structure).
Details
Redox score ?
83
PDB code
3l89
Structure name
human adenovirus type 21 knob in complex with domains scr1 and scr2 of cd46 (membrane cofactor protein, mcp)
Structure deposition date
2009-12-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15529
Residue number A
64
Residue number B
94
Peptide name
Membrane cofactor protein
Ligandability
Cysteine 64 of Membrane cofactor protein
Cysteine 94 of Membrane cofactor protein
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