ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Nucleoside diphosphate kinase A

Intermolecular
Cysteine 145 and cysteine 145
Intramolecular
Cysteine 4 and cysteine 145
A redox-regulated disulphide may form between two units of Nucleoside diphosphate kinase A at cysteines 145 and 145.

Details

Redox score ?
69
PDB code
1jxv
Structure name
crystal structure of human nucleoside diphosphate kinase a
Structure deposition date
2001-09-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
80
Peptide A name
Nucleoside diphosphate kinase A
Peptide B name
Nucleoside diphosphate kinase A
Peptide A accession
P15531
Peptide B accession
P15531
Peptide A residue number
145
Peptide B residue number
145

Ligandability

A redox-regulated disulphide may form within Nucleoside diphosphate kinase A between cysteines 4 and 145.

Details

Redox score ?
85
PDB code
4eno
Structure name
crystal structure of oxidized human nm23-h1
Structure deposition date
2012-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15531
Residue number A
4
Residue number B
145
Peptide name
Nucleoside diphosphate kinase A

Ligandability

Cysteine 4 of Nucleoside diphosphate kinase A

Cysteine 145 of Nucleoside diphosphate kinase A

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