Vascular endothelial growth factor A
Intermolecular
Cysteine 77 and cysteine 86
Cysteine 274 and cysteine 257
Cysteine 257 and cysteine 267
Cysteine 130 and cysteine 77
Cysteine 52 and cysteine 77
Intramolecular
Cysteine 213 and cysteine 227
Cysteine 187 and cysteine 204
Cysteine 83 and cysteine 128
Cysteine 184 and cysteine 202
Cysteine 206 and cysteine 225
More...Cysteine 52 and cysteine 94
Cysteine 87 and cysteine 130
Cysteine 83 and cysteine 94
Cysteine 94 and cysteine 128
Cysteine 52 and cysteine 130
Cysteine 52 and cysteine 128
Cysteine 94 and cysteine 130
Cysteine 52 and cysteine 87
Cysteine 87 and cysteine 94
Cysteine 232 and cysteine 263
Cysteine 266 and cysteine 267
Cysteine 187 and cysteine 225
Cysteine 204 and cysteine 225
Cysteine 206 and cysteine 213
Cysteine 128 and cysteine 130
Cysteine 187 and cysteine 202
Cysteine 184 and cysteine 187
Cysteine 202 and cysteine 204
Cysteine 206 and cysteine 227
Cysteine 184 and cysteine 204
Cysteine 83 and cysteine 130
Cysteine 266 and cysteine 274
Cysteine 204 and cysteine 206
Cysteine 187 and cysteine 206
Cysteine 87 and cysteine 128
Cysteine 86 and cysteine 130
Cysteine 213 and cysteine 225
Cysteine 52 and cysteine 86
Cysteine 225 and cysteine 227
Cysteine 263 and cysteine 267
2fjg V 51 W 60
A redox-regulated disulphide may form between two units of Vascular endothelial growth factor A at cysteines 77 and 86 (51 and 60 respectively in this structure).
Details
Redox score ?
77
PDB code
2fjg
Structure name
structure of the g6 fab, a phage derived fab fragment, in complex with vegf
Structure deposition date
2006-01-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Vascular endothelial growth factor A
Peptide B name
Vascular endothelial growth factor A
Peptide A accession
Q96NW5
Peptide B accession
Q96NW5
Peptide A residue number
77
Peptide B residue number
86
Ligandability
Cysteine 77 of Vascular endothelial growth factor A
Cysteine 86 of Vascular endothelial growth factor A
7kf0 V 68 C 51
A redox-regulated disulphide may form between two units of Isoform L-VEGF206 of Vascular endothelial growth factor A at cysteines 274 and 257 (68 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7kf0
Structure name
crystal structure of bh1 fab variant (cdr h3 loop design 13_0346) in complex with vegf
Structure deposition date
2020-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
Isoform L-VEGF206 of Vascular endothelial growth factor A
Peptide B name
Isoform L-VEGF206 of Vascular endothelial growth factor A
Peptide A accession
P15692-14
Peptide B accession
P15692-14
Peptide A residue number
274
Peptide B residue number
257
Ligandability
Cysteine 274 of Isoform L-VEGF206 of Vascular endothelial growth factor A
Cysteine 257 of Isoform L-VEGF206 of Vascular endothelial growth factor A
7kf0 V 51 C 61
A redox-regulated disulphide may form between two units of Isoform L-VEGF206 of Vascular endothelial growth factor A at cysteines 257 and 267 (51 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7kf0
Structure name
crystal structure of bh1 fab variant (cdr h3 loop design 13_0346) in complex with vegf
Structure deposition date
2020-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Isoform L-VEGF206 of Vascular endothelial growth factor A
Peptide B name
Isoform L-VEGF206 of Vascular endothelial growth factor A
Peptide A accession
P15692-14
Peptide B accession
P15692-14
Peptide A residue number
257
Peptide B residue number
267
Ligandability
Cysteine 257 of Isoform L-VEGF206 of Vascular endothelial growth factor A
Cysteine 267 of Isoform L-VEGF206 of Vascular endothelial growth factor A
7ll8 A 131 B 78
A redox-regulated disulphide may form between two units of Vascular endothelial growth factor A at cysteines 130 and 77 (131 and 78 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7ll8
Structure name
d-protein rfx-v1 bound to the vegfr1 domain 2 site on vegf-a
Structure deposition date
2021-02-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Vascular endothelial growth factor A
Peptide B name
Vascular endothelial growth factor A
Peptide A accession
P15692
Peptide B accession
P15692
Peptide A residue number
130
Peptide B residue number
77
Ligandability
Cysteine 130 of Vascular endothelial growth factor A
Cysteine 77 of Vascular endothelial growth factor A
6zcd V 26 W 51
A redox-regulated disulphide may form between two units of Vascular endothelial growth factor A at cysteines 52 and 77 (26 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6zcd
Structure name
vegf-a 13:107 crystallized with 1c bicyclic peptide
Structure deposition date
2020-06-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Vascular endothelial growth factor A
Peptide B name
Vascular endothelial growth factor A
Peptide A accession
P15692
Peptide B accession
P15692
Peptide A residue number
52
Peptide B residue number
77
Ligandability
Cysteine 52 of Vascular endothelial growth factor A
Cysteine 77 of Vascular endothelial growth factor A
4deq B 195 B 209
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 213 and 227 (195 and 209 respectively in this structure).
Details
Redox score ?
88
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
213
Residue number B
227
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 213 of Vascular endothelial growth factor A
Cysteine 227 of Vascular endothelial growth factor A
4deq B 169 B 186
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 187 and 204 (169 and 186 respectively in this structure).
Details
Redox score ?
87
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
187
Residue number B
204
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 187 of Vascular endothelial growth factor A
Cysteine 204 of Vascular endothelial growth factor A
2fjh W 57 W 102
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 83 and 128 (57 and 102 respectively in this structure).
Details
Redox score ?
86
PDB code
2fjh
Structure name
structure of the b20-4 fab, a phage derived fab fragment, in complex with vegf
Structure deposition date
2006-01-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NW5
Residue number A
83
Residue number B
128
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 83 of Vascular endothelial growth factor A
Cysteine 128 of Vascular endothelial growth factor A
4deq B 166 B 184
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 184 and 202 (166 and 184 respectively in this structure).
Details
Redox score ?
85
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
184
Residue number B
202
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 184 of Vascular endothelial growth factor A
Cysteine 202 of Vascular endothelial growth factor A
4deq A 188 A 207
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 206 and 225 (188 and 207 respectively in this structure).
Details
Redox score ?
84
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
12
Peptide accession
P15692
Residue number A
206
Residue number B
225
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 206 of Vascular endothelial growth factor A
Cysteine 225 of Vascular endothelial growth factor A
2fjg W 26 W 68
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 52 and 94 (26 and 68 respectively in this structure).
Details
Redox score ?
84
PDB code
2fjg
Structure name
structure of the g6 fab, a phage derived fab fragment, in complex with vegf
Structure deposition date
2006-01-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NW5
Residue number A
52
Residue number B
94
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 52 of Vascular endothelial growth factor A
Cysteine 94 of Vascular endothelial growth factor A
3qtk F 54 F 97
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 87 and 130 (54 and 97 respectively in this structure).
Details
Redox score ?
83
PDB code
3qtk
Structure name
the crystal structure of chemically synthesized vegf-a
Structure deposition date
2011-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
87
Residue number B
130
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 87 of Vascular endothelial growth factor A
Cysteine 130 of Vascular endothelial growth factor A
6d3o A 57 A 68
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 83 and 94 (57 and 68 respectively in this structure).
Details
Redox score ?
78
PDB code
6d3o
Structure name
crystal structure of vascular endothelial growth factor (vegf8-109) with hh4, an alpha/beta-peptide with irregular secondary structure
Structure deposition date
2018-04-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
83
Residue number B
94
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 83 of Vascular endothelial growth factor A
Cysteine 94 of Vascular endothelial growth factor A
5hhc B 61 B 95
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 94 and 128 (61 and 95 respectively in this structure).
Details
Redox score ?
75
PDB code
5hhc
Structure name
crystal structure of chemically synthesized heterochiral {rfx037 plus vegf-a} protein complex in space group p21/n
Structure deposition date
2016-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
94
Residue number B
128
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 94 of Vascular endothelial growth factor A
Cysteine 128 of Vascular endothelial growth factor A
2qr0 J 26 J 104
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 52 and 130 (26 and 104 respectively in this structure).
Details
Redox score ?
71
PDB code
2qr0
Structure name
structure of vegf complexed to a fab containing tyr and ser in the cdrs
Structure deposition date
2007-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
52
Residue number B
130
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 52 of Vascular endothelial growth factor A
Cysteine 130 of Vascular endothelial growth factor A
2fjg V 26 V 102
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 52 and 128 (26 and 102 respectively in this structure).
Details
Redox score ?
68
PDB code
2fjg
Structure name
structure of the g6 fab, a phage derived fab fragment, in complex with vegf
Structure deposition date
2006-01-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NW5
Residue number A
52
Residue number B
128
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 52 of Vascular endothelial growth factor A
Cysteine 128 of Vascular endothelial growth factor A
2fjg W 68 W 104
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 94 and 130 (68 and 104 respectively in this structure).
Details
Redox score ?
68
PDB code
2fjg
Structure name
structure of the g6 fab, a phage derived fab fragment, in complex with vegf
Structure deposition date
2006-01-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NW5
Residue number A
94
Residue number B
130
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 94 of Vascular endothelial growth factor A
Cysteine 130 of Vascular endothelial growth factor A
4qaf C 26 C 61
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 52 and 87 (26 and 61 respectively in this structure).
Details
Redox score ?
67
PDB code
4qaf
Structure name
crystal structure of an engineered lipocalin (anticalin) in complex with vegf(8-109)
Structure deposition date
2014-05-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
52
Residue number B
87
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 52 of Vascular endothelial growth factor A
Cysteine 87 of Vascular endothelial growth factor A
2fjg V 61 V 68
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 87 and 94 (61 and 68 respectively in this structure).
Details
Redox score ?
66
PDB code
2fjg
Structure name
structure of the g6 fab, a phage derived fab fragment, in complex with vegf
Structure deposition date
2006-01-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NW5
Residue number A
87
Residue number B
94
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 87 of Vascular endothelial growth factor A
Cysteine 94 of Vascular endothelial growth factor A
7kf0 C 26 C 57
A redox-regulated disulphide may form within Isoform L-VEGF206 of Vascular endothelial growth factor A between cysteines 232 and 263 (26 and 57 respectively in this structure).
Details
Redox score ?
65
PDB code
7kf0
Structure name
crystal structure of bh1 fab variant (cdr h3 loop design 13_0346) in complex with vegf
Structure deposition date
2020-10-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692-14
Residue number A
232
Residue number B
263
Peptide name
Isoform L-VEGF206 of Vascular endothelial growth factor A
Ligandability
Cysteine 232 of Isoform L-VEGF206 of Vascular endothelial growth factor A
Cysteine 263 of Isoform L-VEGF206 of Vascular endothelial growth factor A
7kf1 C 60 C 61
A redox-regulated disulphide may form within Isoform L-VEGF206 of Vascular endothelial growth factor A between cysteines 266 and 267 (60 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7kf1
Structure name
crystal structure of bh1 fab variant (cdr h3 loop design 14_0130) in complex with vegf
Structure deposition date
2020-10-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
nan
Peptide accession
P15692-14
Residue number A
266
Residue number B
267
Peptide name
Isoform L-VEGF206 of Vascular endothelial growth factor A
Ligandability
Cysteine 266 of Isoform L-VEGF206 of Vascular endothelial growth factor A
Cysteine 267 of Isoform L-VEGF206 of Vascular endothelial growth factor A
4deq B 169 B 207
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 187 and 225 (169 and 207 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
187
Residue number B
225
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 187 of Vascular endothelial growth factor A
Cysteine 225 of Vascular endothelial growth factor A
4deq B 186 B 207
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 204 and 225 (186 and 207 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
204
Residue number B
225
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 204 of Vascular endothelial growth factor A
Cysteine 225 of Vascular endothelial growth factor A
4deq B 188 B 195
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 206 and 213 (188 and 195 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
206
Residue number B
213
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 206 of Vascular endothelial growth factor A
Cysteine 213 of Vascular endothelial growth factor A
3qtk B 95 B 97
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 128 and 130 (95 and 97 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
3qtk
Structure name
the crystal structure of chemically synthesized vegf-a
Structure deposition date
2011-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
128
Residue number B
130
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 128 of Vascular endothelial growth factor A
Cysteine 130 of Vascular endothelial growth factor A
4deq B 169 B 184
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 187 and 202 (169 and 184 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
187
Residue number B
202
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 187 of Vascular endothelial growth factor A
Cysteine 202 of Vascular endothelial growth factor A
4deq B 166 B 169
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 184 and 187 (166 and 169 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
184
Residue number B
187
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 184 of Vascular endothelial growth factor A
Cysteine 187 of Vascular endothelial growth factor A
4deq A 184 A 186
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 202 and 204 (184 and 186 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
202
Residue number B
204
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 202 of Vascular endothelial growth factor A
Cysteine 204 of Vascular endothelial growth factor A
4deq B 188 B 209
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 206 and 227 (188 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
206
Residue number B
227
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 206 of Vascular endothelial growth factor A
Cysteine 227 of Vascular endothelial growth factor A
4deq A 166 A 186
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 184 and 204 (166 and 186 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
184
Residue number B
204
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 184 of Vascular endothelial growth factor A
Cysteine 204 of Vascular endothelial growth factor A
1tzi V 57 V 104
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 83 and 130 (57 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
1tzi
Structure name
crystal structure of the fab yads2 complexed with h-vegf
Structure deposition date
2004-07-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
83
Residue number B
130
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 83 of Vascular endothelial growth factor A
Cysteine 130 of Vascular endothelial growth factor A
7kf0 C 60 C 68
A redox-regulated disulphide may form within Isoform L-VEGF206 of Vascular endothelial growth factor A between cysteines 266 and 274 (60 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7kf0
Structure name
crystal structure of bh1 fab variant (cdr h3 loop design 13_0346) in complex with vegf
Structure deposition date
2020-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692-14
Residue number A
266
Residue number B
274
Peptide name
Isoform L-VEGF206 of Vascular endothelial growth factor A
Ligandability
Cysteine 266 of Isoform L-VEGF206 of Vascular endothelial growth factor A
Cysteine 274 of Isoform L-VEGF206 of Vascular endothelial growth factor A
4deq B 186 B 188
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 204 and 206 (186 and 188 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
204
Residue number B
206
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 204 of Vascular endothelial growth factor A
Cysteine 206 of Vascular endothelial growth factor A
4deq B 169 B 188
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 187 and 206 (169 and 188 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
187
Residue number B
206
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 187 of Vascular endothelial growth factor A
Cysteine 206 of Vascular endothelial growth factor A
4qaf C 61 C 102
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 87 and 128 (61 and 102 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4qaf
Structure name
crystal structure of an engineered lipocalin (anticalin) in complex with vegf(8-109)
Structure deposition date
2014-05-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
87
Residue number B
128
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 87 of Vascular endothelial growth factor A
Cysteine 128 of Vascular endothelial growth factor A
2qr0 P 60 P 104
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 86 and 130 (60 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
2qr0
Structure name
structure of vegf complexed to a fab containing tyr and ser in the cdrs
Structure deposition date
2007-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
86
Residue number B
130
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 86 of Vascular endothelial growth factor A
Cysteine 130 of Vascular endothelial growth factor A
4deq A 195 A 207
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 213 and 225 (195 and 207 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
nan
Peptide accession
P15692
Residue number A
213
Residue number B
225
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 213 of Vascular endothelial growth factor A
Cysteine 225 of Vascular endothelial growth factor A
2fjh V 26 V 60
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 52 and 86 (26 and 60 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
2fjh
Structure name
structure of the b20-4 fab, a phage derived fab fragment, in complex with vegf
Structure deposition date
2006-01-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
nan
Peptide accession
Q96NW5
Residue number A
52
Residue number B
86
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 52 of Vascular endothelial growth factor A
Cysteine 86 of Vascular endothelial growth factor A
4deq B 207 B 209
A redox-regulated disulphide may form within Vascular endothelial growth factor A between cysteines 225 and 227 (207 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
4deq
Structure name
structure of the neuropilin-1/vegf-a complex
Structure deposition date
2012-01-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692
Residue number A
225
Residue number B
227
Peptide name
Vascular endothelial growth factor A
Ligandability
Cysteine 225 of Vascular endothelial growth factor A
Cysteine 227 of Vascular endothelial growth factor A
7kf0 V 57 V 61
A redox-regulated disulphide may form within Isoform L-VEGF206 of Vascular endothelial growth factor A between cysteines 263 and 267 (57 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7kf0
Structure name
crystal structure of bh1 fab variant (cdr h3 loop design 13_0346) in complex with vegf
Structure deposition date
2020-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15692-14
Residue number A
263
Residue number B
267
Peptide name
Isoform L-VEGF206 of Vascular endothelial growth factor A
Ligandability
Cysteine 263 of Isoform L-VEGF206 of Vascular endothelial growth factor A
Cysteine 267 of Isoform L-VEGF206 of Vascular endothelial growth factor A
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