ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger protein 40

Intramolecular
Cysteine 2090 and cysteine 2093
Cysteine 2118 and cysteine 2121
A redox-regulated disulphide may form within Zinc finger protein 40 between cysteines 2090 and 2093 (4 and 7 respectively in this structure).

Details

Redox score ?
87
PDB code
1bbo
Structure name
high-resolution solution structure of the double cys2*his2 zinc finger from the human enhancer binding protein mbp-1
Structure deposition date
1992-05-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
7
% buried
0
Peptide accession
P15822
Residue number A
2090
Residue number B
2093
Peptide name
Zinc finger protein 40

Ligandability

Cysteine 2090 of Zinc finger protein 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2093 of Zinc finger protein 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 40 between cysteines 2118 and 2121 (32 and 35 respectively in this structure).

Details

Redox score ?
86
PDB code
1bbo
Structure name
high-resolution solution structure of the double cys2*his2 zinc finger from the human enhancer binding protein mbp-1
Structure deposition date
1992-05-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
7
% buried
0
Peptide accession
P15822
Residue number A
2118
Residue number B
2121
Peptide name
Zinc finger protein 40

Ligandability

Cysteine 2118 of Zinc finger protein 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2121 of Zinc finger protein 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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