ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta-galactoside alpha-2,6-sialyltransferase 1

Intramolecular
Cysteine 353 and cysteine 364
Cysteine 184 and cysteine 335
Cysteine 142 and cysteine 406
A redox-regulated disulphide may form within Beta-galactoside alpha-2,6-sialyltransferase 1 between cysteines 353 and 364.

Details

Redox score ?
86
PDB code
6qvs
Structure name
unliganded structure of the human wild type beta-galactoside alpha-2, 6-sialyltransferase 1 (st6gal1)
Structure deposition date
2019-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15907
Residue number A
353
Residue number B
364
Peptide name
Beta-galactoside alpha-2,6-sialyltransferase 1

Ligandability

Cysteine 353 of Beta-galactoside alpha-2,6-sialyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of Beta-galactoside alpha-2,6-sialyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-galactoside alpha-2,6-sialyltransferase 1 between cysteines 184 and 335.

Details

Redox score ?
83
PDB code
4js2
Structure name
crystal structure of human beta-galactoside alpha-2,6- sialyltransferase 1 in complex with cmp
Structure deposition date
2013-03-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15907
Residue number A
184
Residue number B
335
Peptide name
Beta-galactoside alpha-2,6-sialyltransferase 1

Ligandability

Cysteine 184 of Beta-galactoside alpha-2,6-sialyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Beta-galactoside alpha-2,6-sialyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-galactoside alpha-2,6-sialyltransferase 1 between cysteines 142 and 406.

Details

Redox score ?
78
PDB code
4js1
Structure name
crystal structure of human beta-galactoside alpha-2,6- sialyltransferase 1 in complex with cytidine and phosphate
Structure deposition date
2013-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
P15907
Residue number A
142
Residue number B
406
Peptide name
Beta-galactoside alpha-2,6-sialyltransferase 1

Ligandability

Cysteine 142 of Beta-galactoside alpha-2,6-sialyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 406 of Beta-galactoside alpha-2,6-sialyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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