ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Desmoplakin

Intramolecular
Cysteine 367 and cysteine 467
Cysteine 2433 and cysteine 2442
Cysteine 2259 and cysteine 2442
Cysteine 2259 and cysteine 2433
A redox-regulated disulphide may form within Desmoplakin between cysteines 367 and 467.

Details

Redox score ?
75
PDB code
3r6n
Structure name
crystal structure of a rigid four spectrin repeat fragment of the human desmoplakin plakin domain
Structure deposition date
2011-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
82
Peptide accession
P15924
Residue number A
367
Residue number B
467
Peptide name
Desmoplakin

Ligandability

Cysteine 367 of Desmoplakin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 467 of Desmoplakin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Desmoplakin between cysteines 2433 and 2442. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
1lm7
Structure name
structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Structure deposition date
2002-04-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
78
Peptide accession
P15924
Residue number A
2433
Residue number B
2442
Peptide name
Desmoplakin

Ligandability

Cysteine 2433 of Desmoplakin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2442 of Desmoplakin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Desmoplakin between cysteines 2259 and 2442. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1lm7
Structure name
structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Structure deposition date
2002-04-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
86
Peptide accession
P15924
Residue number A
2259
Residue number B
2442
Peptide name
Desmoplakin

Ligandability

Cysteine 2259 of Desmoplakin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2442 of Desmoplakin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Desmoplakin between cysteines 2259 and 2433. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
1lm7
Structure name
structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Structure deposition date
2002-04-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
93
Peptide accession
P15924
Residue number A
2259
Residue number B
2433
Peptide name
Desmoplakin

Ligandability

Cysteine 2259 of Desmoplakin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2433 of Desmoplakin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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