a tool for identifying drug-targetable redox-active disulphides

Cytochrome c oxidase subunit 7C, mitochondrial

Intermolecular

Cysteine 42 and cysteine 47 of Cytochrome c oxidase subunit 8A, mitochondrial

A redox-regulated disulphide may form between cysteine 42 of Cytochrome c oxidase subunit 7C, mitochondrial and cysteine 47 of Cytochrome c oxidase subunit 8A, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

51

PDB code

Structure name

structure of human cytochrome c oxidase

Structure deposition date

2018-01-22

Thiol separation (Å)

8

Half-sphere exposure sum ?

66

Minimum pK_a ?

9

% buried

54

Peptide A name

Cytochrome c oxidase subunit 7C, mitochondrial

Peptide B name

Cytochrome c oxidase subunit 8A, mitochondrial

Peptide A accession

Peptide B accession

Peptide A residue number

42

Peptide B residue number

47

Ligandability

Cysteine 42 of Cytochrome c oxidase subunit 7C, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Cytochrome c oxidase subunit 8A, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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