Metalloproteinase inhibitor 2
Intramolecular
Cysteine 154 and cysteine 98
Cysteine 159 and cysteine 164
Cysteine 27 and cysteine 98
Cysteine 154 and cysteine 201
Cysteine 172 and cysteine 193
Cysteine 39 and cysteine 152
Cysteine 29 and cysteine 127
Cysteine 27 and cysteine 127
Cysteine 27 and cysteine 29
Cysteine 154 and cysteine 29
More...Cysteine 154 and cysteine 193
Cysteine 154 and cysteine 172
Cysteine 193 and cysteine 201
Cysteine 98 and cysteine 127
Cysteine 172 and cysteine 201
Cysteine 154 and cysteine 127
Cysteine 29 and cysteine 98
Cysteine 152 and cysteine 154
Cysteine 39 and cysteine 154
Cysteine 39 and cysteine 193
Cysteine 39 and cysteine 201
2tmp A 1 A 72
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 154 and 98 (1 and 72 respectively in this structure).
Details
Redox score ?
88
PDB code
2tmp
Structure name
n-terminal domain of tissue inhibitor of metalloproteinase-2 (n-timp- 2), nmr, 49 structures
Structure deposition date
1998-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
154
Residue number B
98
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 154 of Metalloproteinase inhibitor 2
Cysteine 98 of Metalloproteinase inhibitor 2
1buv T 1133 T 1138
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 159 and 164 (1133 and 1138 respectively in this structure).
Details
Redox score ?
86
PDB code
1buv
Structure name
crystal structure of the mt1-mmp-timp-2 complex
Structure deposition date
1998-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16368
Residue number A
159
Residue number B
164
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 159 of Metalloproteinase inhibitor 2
Cysteine 164 of Metalloproteinase inhibitor 2
1buv T 1001 T 1072
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 27 and 98 (1001 and 1072 respectively in this structure).
Details
Redox score ?
86
PDB code
1buv
Structure name
crystal structure of the mt1-mmp-timp-2 complex
Structure deposition date
1998-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16368
Residue number A
27
Residue number B
98
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 27 of Metalloproteinase inhibitor 2
Cysteine 98 of Metalloproteinase inhibitor 2
1gxd D 128 D 175
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 154 and 201 (128 and 175 respectively in this structure).
Details
Redox score ?
85
PDB code
1gxd
Structure name
prommp-2/timp-2 complex
Structure deposition date
2002-04-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
154
Residue number B
201
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 154 of Metalloproteinase inhibitor 2
Cysteine 201 of Metalloproteinase inhibitor 2
1br9 A 146 A 167
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 172 and 193 (146 and 167 respectively in this structure).
Details
Redox score ?
82
PDB code
1br9
Structure name
human tissue inhibitor of metalloproteinase-2
Structure deposition date
1998-08-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
172
Residue number B
193
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 172 of Metalloproteinase inhibitor 2
Cysteine 193 of Metalloproteinase inhibitor 2
1gxd D 13 D 126
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 39 and 152 (13 and 126 respectively in this structure).
Details
Redox score ?
81
PDB code
1gxd
Structure name
prommp-2/timp-2 complex
Structure deposition date
2002-04-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
39
Residue number B
152
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 39 of Metalloproteinase inhibitor 2
Cysteine 152 of Metalloproteinase inhibitor 2
1bqq T 1003 T 1101
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 29 and 127 (1003 and 1101 respectively in this structure).
Details
Redox score ?
78
PDB code
1bqq
Structure name
crystal structure of the mt1-mmp--timp-2 complex
Structure deposition date
1998-08-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16368
Residue number A
29
Residue number B
127
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 29 of Metalloproteinase inhibitor 2
Cysteine 127 of Metalloproteinase inhibitor 2
1bqq T 1001 T 1101
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 27 and 127 (1001 and 1101 respectively in this structure).
Details
Redox score ?
77
PDB code
1bqq
Structure name
crystal structure of the mt1-mmp--timp-2 complex
Structure deposition date
1998-08-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16368
Residue number A
27
Residue number B
127
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 27 of Metalloproteinase inhibitor 2
Cysteine 127 of Metalloproteinase inhibitor 2
4ilw A 1 A 3
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 27 and 29 (1 and 3 respectively in this structure).
Details
Redox score ?
76
PDB code
4ilw
Structure name
complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2)
Structure deposition date
2013-01-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
27
Residue number B
29
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 27 of Metalloproteinase inhibitor 2
Cysteine 29 of Metalloproteinase inhibitor 2
2tmp A 1 A 3
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 154 and 29 (1 and 3 respectively in this structure).
Details
Redox score ?
73
PDB code
2tmp
Structure name
n-terminal domain of tissue inhibitor of metalloproteinase-2 (n-timp- 2), nmr, 49 structures
Structure deposition date
1998-05-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
154
Residue number B
29
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 154 of Metalloproteinase inhibitor 2
Cysteine 29 of Metalloproteinase inhibitor 2
1br9 A 128 A 167
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 154 and 193 (128 and 167 respectively in this structure).
Details
Redox score ?
72
PDB code
1br9
Structure name
human tissue inhibitor of metalloproteinase-2
Structure deposition date
1998-08-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
154
Residue number B
193
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 154 of Metalloproteinase inhibitor 2
Cysteine 193 of Metalloproteinase inhibitor 2
1gxd D 128 D 146
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 154 and 172 (128 and 146 respectively in this structure).
Details
Redox score ?
71
PDB code
1gxd
Structure name
prommp-2/timp-2 complex
Structure deposition date
2002-04-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
154
Residue number B
172
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 154 of Metalloproteinase inhibitor 2
Cysteine 172 of Metalloproteinase inhibitor 2
1bqq T 1167 T 1175
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 193 and 201 (1167 and 1175 respectively in this structure).
Details
Redox score ?
67
PDB code
1bqq
Structure name
crystal structure of the mt1-mmp--timp-2 complex
Structure deposition date
1998-08-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16368
Residue number A
193
Residue number B
201
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 193 of Metalloproteinase inhibitor 2
Cysteine 201 of Metalloproteinase inhibitor 2
4ilw A 72 A 101
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 98 and 127 (72 and 101 respectively in this structure).
Details
Redox score ?
66
PDB code
4ilw
Structure name
complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2)
Structure deposition date
2013-01-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
98
Residue number B
127
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 98 of Metalloproteinase inhibitor 2
Cysteine 127 of Metalloproteinase inhibitor 2
1gxd D 146 D 175
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 172 and 201 (146 and 175 respectively in this structure).
Details
Redox score ?
65
PDB code
1gxd
Structure name
prommp-2/timp-2 complex
Structure deposition date
2002-04-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
172
Residue number B
201
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 172 of Metalloproteinase inhibitor 2
Cysteine 201 of Metalloproteinase inhibitor 2
2tmp A 1 A 101
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 154 and 127 (1 and 101 respectively in this structure).
Details
Redox score ?
60
PDB code
2tmp
Structure name
n-terminal domain of tissue inhibitor of metalloproteinase-2 (n-timp- 2), nmr, 49 structures
Structure deposition date
1998-05-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
154
Residue number B
127
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 154 of Metalloproteinase inhibitor 2
Cysteine 127 of Metalloproteinase inhibitor 2
1buv T 1003 T 1072
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 29 and 98 (1003 and 1072 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
1buv
Structure name
crystal structure of the mt1-mmp-timp-2 complex
Structure deposition date
1998-09-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16368
Residue number A
29
Residue number B
98
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 29 of Metalloproteinase inhibitor 2
Cysteine 98 of Metalloproteinase inhibitor 2
4ilw A 126 A 128
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 152 and 154 (126 and 128 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4ilw
Structure name
complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2)
Structure deposition date
2013-01-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
152
Residue number B
154
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 152 of Metalloproteinase inhibitor 2
Cysteine 154 of Metalloproteinase inhibitor 2
4ilw A 13 A 128
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 39 and 154 (13 and 128 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4ilw
Structure name
complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2)
Structure deposition date
2013-01-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
39
Residue number B
154
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 39 of Metalloproteinase inhibitor 2
Cysteine 154 of Metalloproteinase inhibitor 2
1br9 A 13 A 167
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 39 and 193 (13 and 167 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1br9
Structure name
human tissue inhibitor of metalloproteinase-2
Structure deposition date
1998-08-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
39
Residue number B
193
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 39 of Metalloproteinase inhibitor 2
Cysteine 193 of Metalloproteinase inhibitor 2
1br9 A 13 A 175
A redox-regulated disulphide may form within Metalloproteinase inhibitor 2 between cysteines 39 and 201 (13 and 175 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
1br9
Structure name
human tissue inhibitor of metalloproteinase-2
Structure deposition date
1998-08-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16035
Residue number A
39
Residue number B
201
Peptide name
Metalloproteinase inhibitor 2
Ligandability
Cysteine 39 of Metalloproteinase inhibitor 2
Cysteine 201 of Metalloproteinase inhibitor 2
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