ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Polyunsaturated fatty acid lipoxygenase ALOX15

Intramolecular
Cysteine 78 and cysteine 97
Cysteine 533 and cysteine 537
Cysteine 500 and cysteine 533
Cysteine 7 and cysteine 78
Cysteine 443 and cysteine 533
Cysteine 379 and cysteine 500
A redox-regulated disulphide may form within Polyunsaturated fatty acid lipoxygenase ALOX15 between cysteines 78 and 97.

Details

Redox score ?
71
PDB code
2p0m
Structure name
revised structure of rabbit reticulocyte 15s-lipoxygenase
Structure deposition date
2007-02-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
7
% buried
100
Peptide accession
P12530
Residue number A
78
Residue number B
97
Peptide name
Polyunsaturated fatty acid lipoxygenase ALOX15

Ligandability

Cysteine 78 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polyunsaturated fatty acid lipoxygenase ALOX15 between cysteines 533 and 537. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1lox
Structure name
rabbit reticulocyte 15-lipoxygenase
Structure deposition date
1997-10-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
P12530
Residue number A
533
Residue number B
537
Peptide name
Polyunsaturated fatty acid lipoxygenase ALOX15

Ligandability

Cysteine 533 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 537 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polyunsaturated fatty acid lipoxygenase ALOX15 between cysteines 500 and 533. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2p0m
Structure name
revised structure of rabbit reticulocyte 15s-lipoxygenase
Structure deposition date
2007-02-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
92
Peptide accession
P12530
Residue number A
500
Residue number B
533
Peptide name
Polyunsaturated fatty acid lipoxygenase ALOX15

Ligandability

Cysteine 500 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polyunsaturated fatty acid lipoxygenase ALOX15 between cysteines 7 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2p0m
Structure name
revised structure of rabbit reticulocyte 15s-lipoxygenase
Structure deposition date
2007-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
72
Peptide accession
P12530
Residue number A
7
Residue number B
78
Peptide name
Polyunsaturated fatty acid lipoxygenase ALOX15

Ligandability

Cysteine 7 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polyunsaturated fatty acid lipoxygenase ALOX15 between cysteines 443 and 533. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3rde
Structure name
crystal structure of the catalytic domain of porcine leukocyte 12- lipoxygenase
Structure deposition date
2011-04-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
90
Peptide accession
P16469
Residue number A
443
Residue number B
533
Peptide name
Polyunsaturated fatty acid lipoxygenase ALOX15

Ligandability

Cysteine 443 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polyunsaturated fatty acid lipoxygenase ALOX15 between cysteines 379 and 500. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
2p0m
Structure name
revised structure of rabbit reticulocyte 15s-lipoxygenase
Structure deposition date
2007-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
88
Peptide accession
P12530
Residue number A
379
Residue number B
500
Peptide name
Polyunsaturated fatty acid lipoxygenase ALOX15

Ligandability

Cysteine 379 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 500 of Polyunsaturated fatty acid lipoxygenase ALOX15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: