ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Atrial natriuretic peptide receptor 1

Intramolecular
Cysteine 451 and cysteine 460
Cysteine 88 and cysteine 114
Cysteine 192 and cysteine 241
A redox-regulated disulphide may form within Atrial natriuretic peptide receptor 1 between cysteines 451 and 460 (423 and 432 respectively in this structure).

Details

Redox score ?
89
PDB code
1dp4
Structure name
dimerized hormone binding domain of the atrial natriuretic peptide receptor
Structure deposition date
1999-12-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
31
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18910
Residue number A
451
Residue number B
460
Peptide name
Atrial natriuretic peptide receptor 1

Ligandability

Cysteine 451 of Atrial natriuretic peptide receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 460 of Atrial natriuretic peptide receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Atrial natriuretic peptide receptor 1 between cysteines 88 and 114 (60 and 86 respectively in this structure).

Details

Redox score ?
82
PDB code
7brl
Structure name
atrial natriuretic peptide receptor complexed with deletion mutant of rat atrial natriuretic peptide[4-17,23]
Structure deposition date
2020-03-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18910
Residue number A
88
Residue number B
114
Peptide name
Atrial natriuretic peptide receptor 1

Ligandability

Cysteine 88 of Atrial natriuretic peptide receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Atrial natriuretic peptide receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Atrial natriuretic peptide receptor 1 between cysteines 192 and 241 (164 and 213 respectively in this structure).

Details

Redox score ?
78
PDB code
7brh
Structure name
atrial natriuretic peptide receptor complexed with human atrial natriuretic peptide
Structure deposition date
2020-03-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18910
Residue number A
192
Residue number B
241
Peptide name
Atrial natriuretic peptide receptor 1

Ligandability

Cysteine 192 of Atrial natriuretic peptide receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of Atrial natriuretic peptide receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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