ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

CD44 antigen

Intermolecular
Cysteine 77 and cysteine 77
Intramolecular
Cysteine 77 and cysteine 97
Cysteine 28 and cysteine 129
Cysteine 53 and cysteine 118
A redox-regulated disulphide may form between two units of CD44 antigen at cysteines 77 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4pz3
Structure name
high-resolution crystal structure of the human cd44 hyaluronan binding domain complex with undefined peptides
Structure deposition date
2014-03-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
CD44 antigen
Peptide B name
CD44 antigen
Peptide A accession
P16070
Peptide B accession
P16070
Peptide A residue number
77
Peptide B residue number
77

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CD44 antigen between cysteines 77 and 97.

Details

Redox score ?
84
PDB code
1poz
Structure name
solution structure of the hyaluronan binding domain of human cd44
Structure deposition date
2003-06-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16208
Residue number A
77
Residue number B
97
Peptide name
CD44 antigen

Ligandability

Cysteine 77 of CD44 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of CD44 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CD44 antigen between cysteines 28 and 129.

Details

Redox score ?
81
PDB code
1poz
Structure name
solution structure of the hyaluronan binding domain of human cd44
Structure deposition date
2003-06-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16208
Residue number A
28
Residue number B
129
Peptide name
CD44 antigen

Ligandability

Cysteine 28 of CD44 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of CD44 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CD44 antigen between cysteines 53 and 118.

Details

Redox score ?
79
PDB code
1poz
Structure name
solution structure of the hyaluronan binding domain of human cd44
Structure deposition date
2003-06-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16208
Residue number A
53
Residue number B
118
Peptide name
CD44 antigen

Ligandability

Cysteine 53 of CD44 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of CD44 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: