ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Platelet-derived growth factor receptor alpha

Intramolecular
Cysteine 49 and cysteine 100
Cysteine 235 and cysteine 290
Cysteine 150 and cysteine 189
Cysteine 677 and cysteine 835
A redox-regulated disulphide may form within Platelet-derived growth factor receptor alpha between cysteines 49 and 100.

Details

Redox score ?
83
PDB code
7lbf
Structure name
cryoem structure of the hcmv trimer ghglgo in complex with human platelet-derived growth factor receptor alpha and neutralizing fabs 13h11 and msl-109
Structure deposition date
2021-01-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16234
Residue number A
49
Residue number B
100
Peptide name
Platelet-derived growth factor receptor alpha

Ligandability

Cysteine 49 of Platelet-derived growth factor receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Platelet-derived growth factor receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet-derived growth factor receptor alpha between cysteines 235 and 290.

Details

Redox score ?
81
PDB code
7ram
Structure name
cryo-em structure of the hcmv ghglgo trimer derived from ad169 and tr strains in complex with pdgfralpha
Structure deposition date
2021-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16234
Residue number A
235
Residue number B
290
Peptide name
Platelet-derived growth factor receptor alpha

Ligandability

Cysteine 235 of Platelet-derived growth factor receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 290 of Platelet-derived growth factor receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet-derived growth factor receptor alpha between cysteines 150 and 189.

Details

Redox score ?
80
PDB code
7ram
Structure name
cryo-em structure of the hcmv ghglgo trimer derived from ad169 and tr strains in complex with pdgfralpha
Structure deposition date
2021-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16234
Residue number A
150
Residue number B
189
Peptide name
Platelet-derived growth factor receptor alpha

Ligandability

Cysteine 150 of Platelet-derived growth factor receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Platelet-derived growth factor receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet-derived growth factor receptor alpha between cysteines 677 and 835. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6joi
Structure name
crystal structure of pdgfra t674i in complex with crenolanib by co- crystallization
Structure deposition date
2019-03-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
96
Peptide accession
P16234
Residue number A
677
Residue number B
835
Peptide name
Platelet-derived growth factor receptor alpha

Ligandability

Cysteine 677 of Platelet-derived growth factor receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 835 of Platelet-derived growth factor receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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