ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta-galactosidase

Intramolecular
Cysteine 626 and cysteine 634
Cysteine 195 and cysteine 230
A redox-regulated disulphide may form within Beta-galactosidase between cysteines 626 and 634.

Details

Redox score ?
85
PDB code
3thd
Structure name
crystal structure of human beta-galactosidase in complex with 1- deoxygalactonojirimycin
Structure deposition date
2011-08-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16278
Residue number A
626
Residue number B
634
Peptide name
Beta-galactosidase

Ligandability

Cysteine 626 of Beta-galactosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 634 of Beta-galactosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-galactosidase between cysteines 195 and 230.

Details

Redox score ?
82
PDB code
3thd
Structure name
crystal structure of human beta-galactosidase in complex with 1- deoxygalactonojirimycin
Structure deposition date
2011-08-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16278
Residue number A
195
Residue number B
230
Peptide name
Beta-galactosidase

Ligandability

Cysteine 195 of Beta-galactosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Beta-galactosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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