ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Platelet endothelial cell adhesion molecule

Intramolecular
Cysteine 152 and cysteine 206
Cysteine 57 and cysteine 109
A redox-regulated disulphide may form within Platelet endothelial cell adhesion molecule between cysteines 152 and 206 (125 and 179 respectively in this structure).

Details

Redox score ?
83
PDB code
5c14
Structure name
crystal structure of pecam-1 d1d2 domain
Structure deposition date
2015-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16284
Residue number A
152
Residue number B
206
Peptide name
Platelet endothelial cell adhesion molecule

Ligandability

Cysteine 152 of Platelet endothelial cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Platelet endothelial cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet endothelial cell adhesion molecule between cysteines 57 and 109 (30 and 82 respectively in this structure).

Details

Redox score ?
81
PDB code
5c14
Structure name
crystal structure of pecam-1 d1d2 domain
Structure deposition date
2015-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16284
Residue number A
57
Residue number B
109
Peptide name
Platelet endothelial cell adhesion molecule

Ligandability

Cysteine 57 of Platelet endothelial cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Platelet endothelial cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: