ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Intramolecular
Cysteine 237 and cysteine 265
Cysteine 175 and cysteine 187
Cysteine 162 and cysteine 265
Cysteine 162 and cysteine 237
A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform between cysteines 237 and 265.

Details

Redox score ?
67
PDB code
4or9
Structure name
crystal structure of human calcineurin
Structure deposition date
2014-02-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
77
Peptide accession
P16298
Residue number A
237
Residue number B
265
Peptide name
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Ligandability

Cysteine 237 of Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 265 of Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform between cysteines 175 and 187.

Details

Redox score ?
64
PDB code
4ora
Structure name
crystal structure of a human calcineurin mutant
Structure deposition date
2014-02-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
100
Peptide accession
P16298
Residue number A
175
Residue number B
187
Peptide name
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Ligandability

Cysteine 175 of Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform between cysteines 162 and 265. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4or9
Structure name
crystal structure of human calcineurin
Structure deposition date
2014-02-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
88
Peptide accession
P16298
Residue number A
162
Residue number B
265
Peptide name
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Ligandability

Cysteine 162 of Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 265 of Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform between cysteines 162 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
4ora
Structure name
crystal structure of a human calcineurin mutant
Structure deposition date
2014-02-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
14
% buried
90
Peptide accession
P16298
Residue number A
162
Residue number B
237
Peptide name
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Ligandability

Cysteine 162 of Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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