Cytotoxic T-lymphocyte protein 4
Intermolecular
Cysteine 157 and cysteine 157
Intramolecular
Cysteine 85 and cysteine 103
Cysteine 58 and cysteine 129
Cysteine 85 and cysteine 129
Cysteine 58 and cysteine 103
Cysteine 103 and cysteine 129
Cysteine 58 and cysteine 85
3osk A 122 B 122
A redox-regulated disulphide may form between two units of Cytotoxic T-lymphocyte protein 4 at cysteines 157 and 157 (122 and 122 respectively in this structure).
Details
Redox score ?
91
PDB code
3osk
Structure name
crystal structure of human ctla-4 apo homodimer
Structure deposition date
2010-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
29
Minimum pKa ?
nan
% buried
nan
Peptide A name
Cytotoxic T-lymphocyte protein 4
Peptide B name
Cytotoxic T-lymphocyte protein 4
Peptide A accession
P16410
Peptide B accession
P16410
Peptide A residue number
157
Peptide B residue number
157
Ligandability
3bx7 C 50 C 68
A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 85 and 103 (50 and 68 respectively in this structure).
Details
Redox score ?
84
PDB code
3bx7
Structure name
engineered human lipocalin 2 (lcn2) in complex with the extracellular domain of human ctla-4
Structure deposition date
2008-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16410
Residue number A
85
Residue number B
103
Peptide name
Cytotoxic T-lymphocyte protein 4
Ligandability
Cysteine 85 of Cytotoxic T-lymphocyte protein 4
Cysteine 103 of Cytotoxic T-lymphocyte protein 4
6rp8 c 23 c 94
A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 58 and 129 (23 and 94 respectively in this structure).
Details
Redox score ?
80
PDB code
6rp8
Structure name
crystal structure of ipilimumab fab complexed with ctla-4 at 2
Structure deposition date
2019-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16410
Residue number A
58
Residue number B
129
Peptide name
Cytotoxic T-lymphocyte protein 4
Ligandability
Cysteine 58 of Cytotoxic T-lymphocyte protein 4
Cysteine 129 of Cytotoxic T-lymphocyte protein 4
6rpj E 50 E 94
A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 85 and 129 (50 and 94 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6rpj
Structure name
a non-blocking anti-ctla-4 nanobody complexed with ctla-4
Structure deposition date
2019-05-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16410
Residue number A
85
Residue number B
129
Peptide name
Cytotoxic T-lymphocyte protein 4
Ligandability
Cysteine 85 of Cytotoxic T-lymphocyte protein 4
Cysteine 129 of Cytotoxic T-lymphocyte protein 4
7dv4 C 23 C 68
A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 58 and 103 (23 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7dv4
Structure name
crystal structure of anti-ctla-4 vh domain in complex with human ctla- 4
Structure deposition date
2021-01-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16410
Residue number A
58
Residue number B
103
Peptide name
Cytotoxic T-lymphocyte protein 4
Ligandability
Cysteine 58 of Cytotoxic T-lymphocyte protein 4
Cysteine 103 of Cytotoxic T-lymphocyte protein 4
7dv4 E 68 E 94
A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 103 and 129 (68 and 94 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7dv4
Structure name
crystal structure of anti-ctla-4 vh domain in complex with human ctla- 4
Structure deposition date
2021-01-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16410
Residue number A
103
Residue number B
129
Peptide name
Cytotoxic T-lymphocyte protein 4
Ligandability
Cysteine 103 of Cytotoxic T-lymphocyte protein 4
Cysteine 129 of Cytotoxic T-lymphocyte protein 4
7dv4 E 23 E 50
A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 58 and 85 (23 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7dv4
Structure name
crystal structure of anti-ctla-4 vh domain in complex with human ctla- 4
Structure deposition date
2021-01-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16410
Residue number A
58
Residue number B
85
Peptide name
Cytotoxic T-lymphocyte protein 4
Ligandability
Cysteine 58 of Cytotoxic T-lymphocyte protein 4
Cysteine 85 of Cytotoxic T-lymphocyte protein 4
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