Epithelial cell adhesion molecule
Intramolecular
Cysteine 29 and cysteine 59
Cysteine 38 and cysteine 48
Cysteine 110 and cysteine 116
Cysteine 27 and cysteine 46
Cysteine 118 and cysteine 135
Cysteine 66 and cysteine 99
Cysteine 48 and cysteine 59
Cysteine 29 and cysteine 48
Cysteine 46 and cysteine 59
Cysteine 46 and cysteine 48
More...Cysteine 38 and cysteine 46
Cysteine 29 and cysteine 38
Cysteine 29 and cysteine 46
Cysteine 27 and cysteine 48
Cysteine 38 and cysteine 59
Cysteine 27 and cysteine 38
Cysteine 27 and cysteine 59
Cysteine 116 and cysteine 135
Cysteine 110 and cysteine 135
Cysteine 27 and cysteine 29
Cysteine 116 and cysteine 118
Cysteine 110 and cysteine 118
6i07 D 29 D 59
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 29 and 59.
Details
Redox score ?
87
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
29
Residue number B
59
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 29 of Epithelial cell adhesion molecule
Cysteine 59 of Epithelial cell adhesion molecule
4mzv A 38 A 48
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 38 and 48.
Details
Redox score ?
87
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
38
Residue number B
48
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 38 of Epithelial cell adhesion molecule
Cysteine 48 of Epithelial cell adhesion molecule
4mzv A 110 A 116
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 110 and 116.
Details
Redox score ?
86
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
110
Residue number B
116
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 110 of Epithelial cell adhesion molecule
Cysteine 116 of Epithelial cell adhesion molecule
4mzv A 27 A 46
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 27 and 46.
Details
Redox score ?
86
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
27
Residue number B
46
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 27 of Epithelial cell adhesion molecule
Cysteine 46 of Epithelial cell adhesion molecule
4mzv A 118 A 135
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 118 and 135.
Details
Redox score ?
84
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
118
Residue number B
135
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 118 of Epithelial cell adhesion molecule
Cysteine 135 of Epithelial cell adhesion molecule
6i07 D 66 D 99
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 66 and 99.
Details
Redox score ?
83
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
66
Residue number B
99
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 66 of Epithelial cell adhesion molecule
Cysteine 99 of Epithelial cell adhesion molecule
6i07 C 48 C 59
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 48 and 59.
Details
Redox score ?
76
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
48
Residue number B
59
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 48 of Epithelial cell adhesion molecule
Cysteine 59 of Epithelial cell adhesion molecule
6i07 D 29 D 48
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 29 and 48.
Details
Redox score ?
75
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
29
Residue number B
48
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 29 of Epithelial cell adhesion molecule
Cysteine 48 of Epithelial cell adhesion molecule
6i07 D 46 D 59
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 46 and 59.
Details
Redox score ?
72
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
46
Residue number B
59
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 46 of Epithelial cell adhesion molecule
Cysteine 59 of Epithelial cell adhesion molecule
6i07 D 46 D 48
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 46 and 48.
Details
Redox score ?
71
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
46
Residue number B
48
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 46 of Epithelial cell adhesion molecule
Cysteine 48 of Epithelial cell adhesion molecule
6i07 C 38 C 46
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 38 and 46.
Details
Redox score ?
69
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
38
Residue number B
46
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 38 of Epithelial cell adhesion molecule
Cysteine 46 of Epithelial cell adhesion molecule
6i07 C 29 C 38
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 29 and 38.
Details
Redox score ?
68
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
29
Residue number B
38
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 29 of Epithelial cell adhesion molecule
Cysteine 38 of Epithelial cell adhesion molecule
4mzv A 29 A 46
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 29 and 46.
Details
Redox score ?
67
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
29
Residue number B
46
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 29 of Epithelial cell adhesion molecule
Cysteine 46 of Epithelial cell adhesion molecule
4mzv A 27 A 48
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 27 and 48.
Details
Redox score ?
66
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
27
Residue number B
48
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 27 of Epithelial cell adhesion molecule
Cysteine 48 of Epithelial cell adhesion molecule
6i07 D 38 D 59
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 38 and 59.
Details
Redox score ?
66
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
38
Residue number B
59
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 38 of Epithelial cell adhesion molecule
Cysteine 59 of Epithelial cell adhesion molecule
6i07 C 27 C 38
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 27 and 38.
Details
Redox score ?
62
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
27
Residue number B
38
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 27 of Epithelial cell adhesion molecule
Cysteine 38 of Epithelial cell adhesion molecule
6i07 C 27 C 59
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 27 and 59. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
27
Residue number B
59
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 27 of Epithelial cell adhesion molecule
Cysteine 59 of Epithelial cell adhesion molecule
4mzv A 116 A 135
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 116 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
116
Residue number B
135
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 116 of Epithelial cell adhesion molecule
Cysteine 135 of Epithelial cell adhesion molecule
4mzv A 110 A 135
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 110 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
110
Residue number B
135
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 110 of Epithelial cell adhesion molecule
Cysteine 135 of Epithelial cell adhesion molecule
6i07 C 27 C 29
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 27 and 29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6i07
Structure name
crystal structure of epcam in complex with scfv
Structure deposition date
2018-10-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
27
Residue number B
29
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 27 of Epithelial cell adhesion molecule
Cysteine 29 of Epithelial cell adhesion molecule
4mzv A 116 A 118
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 116 and 118. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
116
Residue number B
118
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 116 of Epithelial cell adhesion molecule
Cysteine 118 of Epithelial cell adhesion molecule
4mzv A 110 A 118
A redox-regulated disulphide may form within Epithelial cell adhesion molecule between cysteines 110 and 118. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4mzv
Structure name
crystal structure of extracellular part of human epcam
Structure deposition date
2013-09-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16422
Residue number A
110
Residue number B
118
Peptide name
Epithelial cell adhesion molecule
Ligandability
Cysteine 110 of Epithelial cell adhesion molecule
Cysteine 118 of Epithelial cell adhesion molecule
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