ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dipeptidase 1

Intermolecular
Cysteine 377 and cysteine 377
Intramolecular
Cysteine 242 and cysteine 274
Cysteine 87 and cysteine 170
A redox-regulated disulphide may form between two units of Dipeptidase 1 at cysteines 377 and 377 (361 and 361 respectively in this structure).

Details

Redox score ?
88
PDB code
1itu
Structure name
human renal dipeptidase complexed with cilastatin
Structure deposition date
2002-02-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide A name
Dipeptidase 1
Peptide B name
Dipeptidase 1
Peptide A accession
P16444
Peptide B accession
P16444
Peptide A residue number
377
Peptide B residue number
377

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidase 1 between cysteines 242 and 274 (226 and 258 respectively in this structure).

Details

Redox score ?
85
PDB code
1itu
Structure name
human renal dipeptidase complexed with cilastatin
Structure deposition date
2002-02-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16444
Residue number A
242
Residue number B
274
Peptide name
Dipeptidase 1

Ligandability

Cysteine 242 of Dipeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Dipeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidase 1 between cysteines 87 and 170 (71 and 154 respectively in this structure).

Details

Redox score ?
79
PDB code
1itq
Structure name
human renal dipeptidase
Structure deposition date
2002-02-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16444
Residue number A
87
Residue number B
170
Peptide name
Dipeptidase 1

Ligandability

Cysteine 87 of Dipeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Dipeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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