a tool for identifying drug-targetable redox-active disulphides

Thyrotropin receptor

Intramolecular

Cysteine 31 and cysteine 41

A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 31 and 41.

Details

Redox score ?

87

PDB code

Structure name

crystal structure of the tsh receptor in complex with a thyroid- stimulating autoantibody

Structure deposition date

2009-01-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

57

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

31

Residue number B

41

Peptide name

Thyrotropin receptor

Ligandability

Cysteine 31 of Thyrotropin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of Thyrotropin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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