a tool for identifying drug-targetable redox-active disulphides

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Intramolecular

Cysteine 86 and cysteine 124

A redox-regulated disulphide may form within Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha between cysteines 86 and 124. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

cryo-em structure of phosphodiesterase 6

Structure deposition date

2018-11-04

Thiol separation (Å)

9

Half-sphere exposure sum ?

71

Minimum pK_a ?

11

% buried

70

Peptide accession

Residue number A

86

Residue number B

124

Peptide name

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Ligandability

Cysteine 86 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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