E-selectin
Intramolecular
Cysteine 148 and cysteine 163
Cysteine 165 and cysteine 174
Cysteine 272 and cysteine 299
Cysteine 193 and cysteine 206
Cysteine 210 and cysteine 237
Cysteine 143 and cysteine 154
Cysteine 255 and cysteine 268
Cysteine 242 and cysteine 286
Cysteine 180 and cysteine 224
Cysteine 40 and cysteine 138
More...Cysteine 111 and cysteine 130
Cysteine 163 and cysteine 174
Cysteine 148 and cysteine 154
Cysteine 148 and cysteine 174
Cysteine 154 and cysteine 163
Cysteine 163 and cysteine 165
Cysteine 143 and cysteine 148
Cysteine 148 and cysteine 165
Cysteine 143 and cysteine 163
Cysteine 268 and cysteine 286
Cysteine 242 and cysteine 268
Cysteine 154 and cysteine 174
Cysteine 206 and cysteine 224
Cysteine 180 and cysteine 206
Cysteine 255 and cysteine 286
Cysteine 242 and cysteine 255
6eyi A 127 A 142
A redox-regulated disulphide may form within E-selectin between cysteines 148 and 163 (127 and 142 respectively in this structure).
Details
Redox score ?
88
PDB code
6eyi
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand bw69669
Structure deposition date
2017-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
148
Residue number B
163
Peptide name
E-selectin
Ligandability
Cysteine 148 of E-selectin
Cysteine 163 of E-selectin
1g1t A 144 A 153
A redox-regulated disulphide may form within E-selectin between cysteines 165 and 174 (144 and 153 respectively in this structure).
Details
Redox score ?
88
PDB code
1g1t
Structure name
crystal structure of e-selectin lectin/egf domains complexed with slex
Structure deposition date
2000-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
165
Residue number B
174
Peptide name
E-selectin
Ligandability
Cysteine 165 of E-selectin
Cysteine 174 of E-selectin
6eyj A 251 A 278
A redox-regulated disulphide may form within E-selectin between cysteines 272 and 299 (251 and 278 respectively in this structure).
Details
Redox score ?
88
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
272
Residue number B
299
Peptide name
E-selectin
Ligandability
Cysteine 272 of E-selectin
Cysteine 299 of E-selectin
4c16 A 172 A 185
A redox-regulated disulphide may form within E-selectin between cysteines 193 and 206 (172 and 185 respectively in this structure).
Details
Redox score ?
88
PDB code
4c16
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic antagonist
Structure deposition date
2013-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
193
Residue number B
206
Peptide name
E-selectin
Ligandability
Cysteine 193 of E-selectin
Cysteine 206 of E-selectin
4csy B 189 B 216
A redox-regulated disulphide may form within E-selectin between cysteines 210 and 237 (189 and 216 respectively in this structure).
Details
Redox score ?
88
PDB code
4csy
Structure name
e-selectin lectin, egf-like and two scr domains complexed with sialyl lewis x
Structure deposition date
2014-03-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
210
Residue number B
237
Peptide name
E-selectin
Ligandability
Cysteine 210 of E-selectin
Cysteine 237 of E-selectin
1g1t A 122 A 133
A redox-regulated disulphide may form within E-selectin between cysteines 143 and 154 (122 and 133 respectively in this structure).
Details
Redox score ?
87
PDB code
1g1t
Structure name
crystal structure of e-selectin lectin/egf domains complexed with slex
Structure deposition date
2000-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
143
Residue number B
154
Peptide name
E-selectin
Ligandability
Cysteine 143 of E-selectin
Cysteine 154 of E-selectin
6eyj A 234 A 247
A redox-regulated disulphide may form within E-selectin between cysteines 255 and 268 (234 and 247 respectively in this structure).
Details
Redox score ?
87
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
255
Residue number B
268
Peptide name
E-selectin
Ligandability
Cysteine 255 of E-selectin
Cysteine 268 of E-selectin
4csy A 221 A 265
A redox-regulated disulphide may form within E-selectin between cysteines 242 and 286 (221 and 265 respectively in this structure).
Details
Redox score ?
86
PDB code
4csy
Structure name
e-selectin lectin, egf-like and two scr domains complexed with sialyl lewis x
Structure deposition date
2014-03-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
242
Residue number B
286
Peptide name
E-selectin
Ligandability
Cysteine 242 of E-selectin
Cysteine 286 of E-selectin
6eyk A 159 A 203
A redox-regulated disulphide may form within E-selectin between cysteines 180 and 224 (159 and 203 respectively in this structure).
Details
Redox score ?
86
PDB code
6eyk
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv355
Structure deposition date
2017-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
180
Residue number B
224
Peptide name
E-selectin
Ligandability
Cysteine 180 of E-selectin
Cysteine 224 of E-selectin
1g1t A 19 A 117
A redox-regulated disulphide may form within E-selectin between cysteines 40 and 138 (19 and 117 respectively in this structure).
Details
Redox score ?
84
PDB code
1g1t
Structure name
crystal structure of e-selectin lectin/egf domains complexed with slex
Structure deposition date
2000-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
40
Residue number B
138
Peptide name
E-selectin
Ligandability
Cysteine 40 of E-selectin
Cysteine 138 of E-selectin
6eyj B 90 B 109
A redox-regulated disulphide may form within E-selectin between cysteines 111 and 130 (90 and 109 respectively in this structure).
Details
Redox score ?
82
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
111
Residue number B
130
Peptide name
E-selectin
Ligandability
Cysteine 111 of E-selectin
Cysteine 130 of E-selectin
6eyj B 142 B 153
A redox-regulated disulphide may form within E-selectin between cysteines 163 and 174 (142 and 153 respectively in this structure).
Details
Redox score ?
74
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
163
Residue number B
174
Peptide name
E-selectin
Ligandability
Cysteine 163 of E-selectin
Cysteine 174 of E-selectin
1g1t A 127 A 133
A redox-regulated disulphide may form within E-selectin between cysteines 148 and 154 (127 and 133 respectively in this structure).
Details
Redox score ?
74
PDB code
1g1t
Structure name
crystal structure of e-selectin lectin/egf domains complexed with slex
Structure deposition date
2000-10-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
148
Residue number B
154
Peptide name
E-selectin
Ligandability
Cysteine 148 of E-selectin
Cysteine 154 of E-selectin
1g1t A 127 A 153
A redox-regulated disulphide may form within E-selectin between cysteines 148 and 174 (127 and 153 respectively in this structure).
Details
Redox score ?
71
PDB code
1g1t
Structure name
crystal structure of e-selectin lectin/egf domains complexed with slex
Structure deposition date
2000-10-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
148
Residue number B
174
Peptide name
E-selectin
Ligandability
Cysteine 148 of E-selectin
Cysteine 174 of E-selectin
6eyi A 133 A 142
A redox-regulated disulphide may form within E-selectin between cysteines 154 and 163 (133 and 142 respectively in this structure).
Details
Redox score ?
71
PDB code
6eyi
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand bw69669
Structure deposition date
2017-11-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
154
Residue number B
163
Peptide name
E-selectin
Ligandability
Cysteine 154 of E-selectin
Cysteine 163 of E-selectin
4c16 A 142 A 144
A redox-regulated disulphide may form within E-selectin between cysteines 163 and 165 (142 and 144 respectively in this structure).
Details
Redox score ?
65
PDB code
4c16
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic antagonist
Structure deposition date
2013-08-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
163
Residue number B
165
Peptide name
E-selectin
Ligandability
Cysteine 163 of E-selectin
Cysteine 165 of E-selectin
6eyj A 122 A 127
A redox-regulated disulphide may form within E-selectin between cysteines 143 and 148 (122 and 127 respectively in this structure).
Details
Redox score ?
63
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
143
Residue number B
148
Peptide name
E-selectin
Ligandability
Cysteine 143 of E-selectin
Cysteine 148 of E-selectin
6eyj A 127 A 144
A redox-regulated disulphide may form within E-selectin between cysteines 148 and 165 (127 and 144 respectively in this structure).
Details
Redox score ?
61
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
148
Residue number B
165
Peptide name
E-selectin
Ligandability
Cysteine 148 of E-selectin
Cysteine 165 of E-selectin
6eyj B 122 B 142
A redox-regulated disulphide may form within E-selectin between cysteines 143 and 163 (122 and 142 respectively in this structure).
Details
Redox score ?
60
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
143
Residue number B
163
Peptide name
E-selectin
Ligandability
Cysteine 143 of E-selectin
Cysteine 163 of E-selectin
6eyk A 247 A 265
A redox-regulated disulphide may form within E-selectin between cysteines 268 and 286 (247 and 265 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6eyk
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv355
Structure deposition date
2017-11-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
268
Residue number B
286
Peptide name
E-selectin
Ligandability
Cysteine 268 of E-selectin
Cysteine 286 of E-selectin
6eyj A 221 A 247
A redox-regulated disulphide may form within E-selectin between cysteines 242 and 268 (221 and 247 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
242
Residue number B
268
Peptide name
E-selectin
Ligandability
Cysteine 242 of E-selectin
Cysteine 268 of E-selectin
4c16 A 133 A 153
A redox-regulated disulphide may form within E-selectin between cysteines 154 and 174 (133 and 153 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4c16
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic antagonist
Structure deposition date
2013-08-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
154
Residue number B
174
Peptide name
E-selectin
Ligandability
Cysteine 154 of E-selectin
Cysteine 174 of E-selectin
4csy B 185 B 203
A redox-regulated disulphide may form within E-selectin between cysteines 206 and 224 (185 and 203 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4csy
Structure name
e-selectin lectin, egf-like and two scr domains complexed with sialyl lewis x
Structure deposition date
2014-03-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
206
Residue number B
224
Peptide name
E-selectin
Ligandability
Cysteine 206 of E-selectin
Cysteine 224 of E-selectin
6eyj B 159 B 185
A redox-regulated disulphide may form within E-selectin between cysteines 180 and 206 (159 and 185 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
180
Residue number B
206
Peptide name
E-selectin
Ligandability
Cysteine 180 of E-selectin
Cysteine 206 of E-selectin
6eyj B 234 B 265
A redox-regulated disulphide may form within E-selectin between cysteines 255 and 286 (234 and 265 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
255
Residue number B
286
Peptide name
E-selectin
Ligandability
Cysteine 255 of E-selectin
Cysteine 286 of E-selectin
6eyj B 221 B 234
A redox-regulated disulphide may form within E-selectin between cysteines 242 and 255 (221 and 234 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6eyj
Structure name
e-selectin lectin, egf-like and two scr domains complexed with glycomimetic ligand nv354
Structure deposition date
2017-11-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16581
Residue number A
242
Residue number B
255
Peptide name
E-selectin
Ligandability
Cysteine 242 of E-selectin
Cysteine 255 of E-selectin
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