ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Platelet glycoprotein 4

Intramolecular
Cysteine 313 and cysteine 322
Cysteine 243 and cysteine 311
Cysteine 272 and cysteine 333
A redox-regulated disulphide may form within Platelet glycoprotein 4 between cysteines 313 and 322.

Details

Redox score ?
86
PDB code
5lgd
Structure name
the cidra domain from mcvar1 pfemp1 bound to cd36
Structure deposition date
2016-07-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16671
Residue number A
313
Residue number B
322
Peptide name
Platelet glycoprotein 4

Ligandability

Cysteine 313 of Platelet glycoprotein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Platelet glycoprotein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein 4 between cysteines 243 and 311.

Details

Redox score ?
83
PDB code
5lgd
Structure name
the cidra domain from mcvar1 pfemp1 bound to cd36
Structure deposition date
2016-07-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16671
Residue number A
243
Residue number B
311
Peptide name
Platelet glycoprotein 4

Ligandability

Cysteine 243 of Platelet glycoprotein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 311 of Platelet glycoprotein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein 4 between cysteines 272 and 333.

Details

Redox score ?
82
PDB code
5lgd
Structure name
the cidra domain from mcvar1 pfemp1 bound to cd36
Structure deposition date
2016-07-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16671
Residue number A
272
Residue number B
333
Peptide name
Platelet glycoprotein 4

Ligandability

Cysteine 272 of Platelet glycoprotein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Platelet glycoprotein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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