Interleukin-7 receptor subunit alpha
Intramolecular
Cysteine 42 and cysteine 57
Cysteine 108 and cysteine 118
Cysteine 74 and cysteine 82
Cysteine 74 and cysteine 108
Cysteine 74 and cysteine 118
Cysteine 82 and cysteine 108
Cysteine 82 and cysteine 118
6p67 J 22 J 37
A redox-regulated disulphide may form within Interleukin-7 receptor subunit alpha between cysteines 42 and 57 (22 and 37 respectively in this structure).
Details
Redox score ?
85
PDB code
6p67
Structure name
crystal structure of a complex of human il-7ralpha with an anti-il- 7ralpha 2b8 fab
Structure deposition date
2019-06-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16871
Residue number A
42
Residue number B
57
Peptide name
Interleukin-7 receptor subunit alpha
Ligandability
Cysteine 42 of Interleukin-7 receptor subunit alpha
Cysteine 57 of Interleukin-7 receptor subunit alpha
3di2 D 88 D 98
A redox-regulated disulphide may form within Interleukin-7 receptor subunit alpha between cysteines 108 and 118 (88 and 98 respectively in this structure).
Details
Redox score ?
83
PDB code
3di2
Structure name
crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain
Structure deposition date
2008-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16871
Residue number A
108
Residue number B
118
Peptide name
Interleukin-7 receptor subunit alpha
Ligandability
Cysteine 108 of Interleukin-7 receptor subunit alpha
Cysteine 118 of Interleukin-7 receptor subunit alpha
3di2 D 54 D 62
A redox-regulated disulphide may form within Interleukin-7 receptor subunit alpha between cysteines 74 and 82 (54 and 62 respectively in this structure).
Details
Redox score ?
81
PDB code
3di2
Structure name
crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain
Structure deposition date
2008-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16871
Residue number A
74
Residue number B
82
Peptide name
Interleukin-7 receptor subunit alpha
Ligandability
Cysteine 74 of Interleukin-7 receptor subunit alpha
Cysteine 82 of Interleukin-7 receptor subunit alpha
6p67 K 54 K 88
A redox-regulated disulphide may form within Interleukin-7 receptor subunit alpha between cysteines 74 and 108 (54 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6p67
Structure name
crystal structure of a complex of human il-7ralpha with an anti-il- 7ralpha 2b8 fab
Structure deposition date
2019-06-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16871
Residue number A
74
Residue number B
108
Peptide name
Interleukin-7 receptor subunit alpha
Ligandability
Cysteine 74 of Interleukin-7 receptor subunit alpha
Cysteine 108 of Interleukin-7 receptor subunit alpha
3up1 A 54 A 98
A redox-regulated disulphide may form within Interleukin-7 receptor subunit alpha between cysteines 74 and 118 (54 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
3up1
Structure name
crystal structure of the unliganded human interleukin-7 receptor extracellular domain
Structure deposition date
2011-11-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16871
Residue number A
74
Residue number B
118
Peptide name
Interleukin-7 receptor subunit alpha
Ligandability
Cysteine 74 of Interleukin-7 receptor subunit alpha
Cysteine 118 of Interleukin-7 receptor subunit alpha
7opb B 82 B 108
A redox-regulated disulphide may form within Interleukin-7 receptor subunit alpha between cysteines 82 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7opb
Structure name
il7r in complex with an antagonist
Structure deposition date
2021-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16871
Residue number A
82
Residue number B
108
Peptide name
Interleukin-7 receptor subunit alpha
Ligandability
Cysteine 82 of Interleukin-7 receptor subunit alpha
Cysteine 108 of Interleukin-7 receptor subunit alpha
6p50 C 62 C 98
A redox-regulated disulphide may form within Interleukin-7 receptor subunit alpha between cysteines 82 and 118 (62 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6p50
Structure name
crystal structure of a complex of human il-7ralpha with an anti-il- 7ralpha fab 4a10
Structure deposition date
2019-05-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16871
Residue number A
82
Residue number B
118
Peptide name
Interleukin-7 receptor subunit alpha
Ligandability
Cysteine 82 of Interleukin-7 receptor subunit alpha
Cysteine 118 of Interleukin-7 receptor subunit alpha
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