1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 at cysteines 624 and 624. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

2dx0

Structure name

crystal structure of the n-terminal sh2 domain of mouse phospholipase c-gamma 2

Structure deposition date

2006-08-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Peptide B name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Peptide A accession

Q8CIH5

Peptide B accession

Q8CIH5

Peptide A residue number

624

Peptide B residue number

624

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 between cysteines 586 and 624.

Details

Redox score ?

PDB code

2dx0

Structure name

crystal structure of the n-terminal sh2 domain of mouse phospholipase c-gamma 2

Structure deposition date

2006-08-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Q8CIH5

Residue number A

586

Residue number B

624

Peptide name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Ligandability

Cysteine 586 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 624 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 between cysteines 496 and 849 (27 and 54 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?