ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger protein 24

Intramolecular
Cysteine 309 and cysteine 312
Cysteine 281 and cysteine 284
A redox-regulated disulphide may form within Zinc finger protein 24 between cysteines 309 and 312 (45 and 48 respectively in this structure).

Details

Redox score ?
88
PDB code
1x6e
Structure name
solution structures of the c2h2 type zinc finger domain of human zinc finger protein 24
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
0
Peptide accession
P17028
Residue number A
309
Residue number B
312
Peptide name
Zinc finger protein 24

Ligandability

Cysteine 309 of Zinc finger protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Zinc finger protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 24 between cysteines 281 and 284 (17 and 20 respectively in this structure).

Details

Redox score ?
86
PDB code
1x6e
Structure name
solution structures of the c2h2 type zinc finger domain of human zinc finger protein 24
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
0
Peptide accession
P17028
Residue number A
281
Residue number B
284
Peptide name
Zinc finger protein 24

Ligandability

Cysteine 281 of Zinc finger protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Zinc finger protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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