ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Aspartate aminotransferase, cytoplasmic

Intramolecular
Cysteine 192 and cysteine 253
A redox-regulated disulphide may form within Aspartate aminotransferase, cytoplasmic between cysteines 192 and 253 (191 and 252 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
3wzf
Structure name
crystal structure of human cytoplasmic aspartate aminotransferase
Structure deposition date
2014-09-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
95
Minimum pKa ?
13
% buried
100
Peptide accession
P17174
Residue number A
192
Residue number B
253
Peptide name
Aspartate aminotransferase, cytoplasmic

Ligandability

Cysteine 192 of Aspartate aminotransferase, cytoplasmic

Cysteine 253 of Aspartate aminotransferase, cytoplasmic

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