ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon alpha/beta receptor 1

Intramolecular
Cysteine 79 and cysteine 87
Cysteine 353 and cysteine 358
Cysteine 283 and cysteine 291
Cysteine 397 and cysteine 419
Cysteine 199 and cysteine 220
A redox-regulated disulphide may form within Interferon alpha/beta receptor 1 between cysteines 79 and 87 (52 and 60 respectively in this structure).

Details

Redox score ?
87
PDB code
3se4
Structure name
human ifnw-ifnar ternary complex
Structure deposition date
2011-06-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17181
Residue number A
79
Residue number B
87
Peptide name
Interferon alpha/beta receptor 1

Ligandability

Cysteine 79 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon alpha/beta receptor 1 between cysteines 353 and 358 (327 and 332 respectively in this structure).

Details

Redox score ?
87
PDB code
3wcy
Structure name
murine ifnar1 in complex with interferon-beta
Structure deposition date
2013-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P33896
Residue number A
353
Residue number B
358
Peptide name
Interferon alpha/beta receptor 1

Ligandability

Cysteine 353 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 358 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon alpha/beta receptor 1 between cysteines 283 and 291 (256 and 264 respectively in this structure).

Details

Redox score ?
87
PDB code
3se3
Structure name
human ifna2-ifnar ternary complex
Structure deposition date
2011-06-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17181
Residue number A
283
Residue number B
291
Peptide name
Interferon alpha/beta receptor 1

Ligandability

Cysteine 283 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon alpha/beta receptor 1 between cysteines 397 and 419 (371 and 393 respectively in this structure).

Details

Redox score ?
81
PDB code
3wcy
Structure name
murine ifnar1 in complex with interferon-beta
Structure deposition date
2013-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P33896
Residue number A
397
Residue number B
419
Peptide name
Interferon alpha/beta receptor 1

Ligandability

Cysteine 397 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 419 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon alpha/beta receptor 1 between cysteines 199 and 220 (172 and 193 respectively in this structure).

Details

Redox score ?
77
PDB code
3s98
Structure name
human ifnar1
Structure deposition date
2011-06-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
6
Peptide accession
P17181
Residue number A
199
Residue number B
220
Peptide name
Interferon alpha/beta receptor 1

Ligandability

Cysteine 199 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Interferon alpha/beta receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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