ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bactericidal permeability-increasing protein

Intramolecular
Cysteine 166 and cysteine 206
Cysteine 163 and cysteine 166
Cysteine 163 and cysteine 206
A redox-regulated disulphide may form within Bactericidal permeability-increasing protein between cysteines 166 and 206 (135 and 175 respectively in this structure).

Details

Redox score ?
87
PDB code
1ewf
Structure name
the 1
Structure deposition date
2000-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17213
Residue number A
166
Residue number B
206
Peptide name
Bactericidal permeability-increasing protein

Ligandability

Cysteine 166 of Bactericidal permeability-increasing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Bactericidal permeability-increasing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bactericidal permeability-increasing protein between cysteines 163 and 166 (132 and 135 respectively in this structure).

Details

Redox score ?
69
PDB code
1bp1
Structure name
crystal structure of bpi, the human bactericidal permeability- increasing protein
Structure deposition date
1997-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
nan
Peptide accession
P17213
Residue number A
163
Residue number B
166
Peptide name
Bactericidal permeability-increasing protein

Ligandability

Cysteine 163 of Bactericidal permeability-increasing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of Bactericidal permeability-increasing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bactericidal permeability-increasing protein between cysteines 163 and 206 (132 and 175 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1ewf
Structure name
the 1
Structure deposition date
2000-04-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
nan
Peptide accession
P17213
Residue number A
163
Residue number B
206
Peptide name
Bactericidal permeability-increasing protein

Ligandability

Cysteine 163 of Bactericidal permeability-increasing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Bactericidal permeability-increasing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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