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Gap junction alpha-1 protein

Intramolecular
Cysteine 65 and cysteine 187 L
Cysteine 61 and cysteine 192
Cysteine 54 and cysteine 198 L
Cysteine 65 and cysteine 192 L
Cysteine 187 and cysteine 192
Cysteine 260 and cysteine 271
Cysteine 61 and cysteine 65 L
Cysteine 65 and cysteine 198 L
Cysteine 187 and cysteine 198
Cysteine 61 and cysteine 187
More...
Cysteine 54 and cysteine 65 L
Cysteine 54 and cysteine 61 L
Cysteine 54 and cysteine 187 L
Cysteine 61 and cysteine 198
Cysteine 54 and cysteine 192 L
Cysteine 192 and cysteine 198
A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 65 and 187.

Details

Redox score ?
84
PDB code
7f93
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in nanodiscs with soybean lipids at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
65
Residue number B
187
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 65 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 61 and 192.

Details

Redox score ?
84
PDB code
7f94
Structure name
structure of c-terminal truncated connexin43/cx43/gja1 gap junction intercellular channel with two conformationally different hemichannels
Structure deposition date
2021-07-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
61
Residue number B
192
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 61 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 54 and 198.

Details

Redox score ?
82
PDB code
7f94
Structure name
structure of c-terminal truncated connexin43/cx43/gja1 gap junction intercellular channel with two conformationally different hemichannels
Structure deposition date
2021-07-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
54
Residue number B
198
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 54 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 65 and 192.

Details

Redox score ?
72
PDB code
7f92
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in lmng/chs detergents at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
65
Residue number B
192
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 65 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 187 and 192.

Details

Redox score ?
70
PDB code
7f93
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in nanodiscs with soybean lipids at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
187
Residue number B
192
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 187 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 260 and 271 (10 and 21 respectively in this structure).

Details

Redox score ?
68
PDB code
1r5s
Structure name
connexin 43 carboxyl terminal domain
Structure deposition date
2003-10-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
20
Minimum pKa ?
9
% buried
0
Peptide accession
P08050
Residue number A
260
Residue number B
271
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 260 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 61 and 65.

Details

Redox score ?
68
PDB code
7f93
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in nanodiscs with soybean lipids at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
61
Residue number B
65
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 61 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 65 and 198.

Details

Redox score ?
67
PDB code
7f92
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in lmng/chs detergents at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
65
Residue number B
198
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 65 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 187 and 198.

Details

Redox score ?
66
PDB code
7f92
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in lmng/chs detergents at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
187
Residue number B
198
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 187 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 61 and 187.

Details

Redox score ?
64
PDB code
7f92
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in lmng/chs detergents at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
61
Residue number B
187
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 61 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 54 and 65.

Details

Redox score ?
63
PDB code
7f94
Structure name
structure of c-terminal truncated connexin43/cx43/gja1 gap junction intercellular channel with two conformationally different hemichannels
Structure deposition date
2021-07-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
54
Residue number B
65
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 54 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 54 and 61. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7f93
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in nanodiscs with soybean lipids at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
54
Residue number B
61
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 54 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 61 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 54 and 187. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7f92
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in lmng/chs detergents at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
54
Residue number B
187
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 54 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 61 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7f94
Structure name
structure of c-terminal truncated connexin43/cx43/gja1 gap junction intercellular channel with two conformationally different hemichannels
Structure deposition date
2021-07-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
61
Residue number B
198
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 61 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 54 and 192. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7f93
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in nanodiscs with soybean lipids at ph ~8
Structure deposition date
2021-07-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
54
Residue number B
192
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 54 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-1 protein between cysteines 192 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7xq9
Structure name
structure of connexin43/cx43/gja1 gap junction intercellular channel in gdn detergents at ph ~8
Structure deposition date
2022-05-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17302
Residue number A
192
Residue number B
198
Peptide name
Gap junction alpha-1 protein

Ligandability

Cysteine 192 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Gap junction alpha-1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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