ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Intramolecular
Cysteine 59 and cysteine 90
Cysteine 69 and cysteine 80
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 between cysteines 59 and 90 (58 and 89 respectively in this structure).

Details

Redox score ?
74
PDB code
7r4g
Structure name
bovine complex i in the presence of im1761092, slack class ii (composite map)
Structure deposition date
2022-02-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
92
Peptide accession
Q02368
Residue number A
59
Residue number B
90
Peptide name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Ligandability

Cysteine 59 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Cysteine 90 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 between cysteines 69 and 80 (68 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7ak6
Structure name
cryo-em structure of nd6-p25l mutant respiratory complex i from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
51
Peptide accession
Q9CR61
Residue number A
69
Residue number B
80
Peptide name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Ligandability

Cysteine 69 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Cysteine 80 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

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