ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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cAMP-dependent protein kinase catalytic subunit alpha

Intermolecular
Cysteine 99 of Protein kinase, cAMP dependent regulatory, type II alpha and cysteine 200
Cysteine 200 and cysteine 98 of cAMP-dependent protein kinase type II-alpha regulatory subunit
Cysteine 200 and cysteine 114 of cAMP-dependent protein kinase type II-beta regulatory subunit
A redox-regulated disulphide may form between cysteine 99 of Protein kinase, cAMP dependent regulatory, type II alpha and cysteine 200 of cAMP-dependent protein kinase catalytic subunit alpha (99 and 199 respectively in this structure).

Details

Redox score ?
61
PDB code
3j4r
Structure name
pseudo-atomic model of the akap18-pka complex in a linear conformation derived from electron microscopy
Structure deposition date
2013-09-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
86
Peptide A name
Protein kinase, cAMP dependent regulatory, type II alpha
Peptide B name
cAMP-dependent protein kinase catalytic subunit alpha
Peptide A accession
Q8K1M3
Peptide B accession
P05132
Peptide A residue number
99
Peptide B residue number
200

Ligandability

Cysteine 99 of Protein kinase, cAMP dependent regulatory, type II alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of cAMP-dependent protein kinase catalytic subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 200 of cAMP-dependent protein kinase catalytic subunit alpha and cysteine 98 of cAMP-dependent protein kinase type II-alpha regulatory subunit (199 and 97 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2qvs
Structure name
crystal structure of type iia holoenzyme of camp-dependent protein kinase
Structure deposition date
2007-08-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
87
Peptide A name
cAMP-dependent protein kinase catalytic subunit alpha
Peptide B name
cAMP-dependent protein kinase type II-alpha regulatory subunit
Peptide A accession
P05132
Peptide B accession
P12367
Peptide A residue number
200
Peptide B residue number
98

Ligandability

Cysteine 200 of cAMP-dependent protein kinase catalytic subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of cAMP-dependent protein kinase type II-alpha regulatory subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 200 of cAMP-dependent protein kinase catalytic subunit alpha and cysteine 114 of cAMP-dependent protein kinase type II-beta regulatory subunit (254 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6wjg
Structure name
pka riibeta holoenzyme with dnajb1-pkac fusion in fibrolamellar hepatoceullar carcinoma
Structure deposition date
2020-04-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
68
Peptide A name
cAMP-dependent protein kinase catalytic subunit alpha
Peptide B name
cAMP-dependent protein kinase type II-beta regulatory subunit
Peptide A accession
P17612
Peptide B accession
P12369
Peptide A residue number
200
Peptide B residue number
114

Ligandability

Cysteine 200 of cAMP-dependent protein kinase catalytic subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of cAMP-dependent protein kinase type II-beta regulatory subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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