Tyrosine aminotransferase
Intermolecular
Cysteine 320 and cysteine 320
Intramolecular
Cysteine 151 and cysteine 275
Cysteine 353 and cysteine 431
Cysteine 404 and cysteine 431
Cysteine 144 and cysteine 275
Cysteine 151 and cysteine 211
Cysteine 144 and cysteine 151
Cysteine 353 and cysteine 404
Cysteine 404 and cysteine 438
Cysteine 211 and cysteine 275
3dyd A 320 B 320
A redox-regulated disulphide may form between two units of Tyrosine aminotransferase at cysteines 320 and 320.
Details
Redox score ?
61
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
103
Minimum pKa ?
8
% buried
100
Peptide A name
Tyrosine aminotransferase
Peptide B name
Tyrosine aminotransferase
Peptide A accession
P17735
Peptide B accession
P17735
Peptide A residue number
320
Peptide B residue number
320
Ligandability
3dyd B 151 B 275
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 151 and 275.
Details
Redox score ?
67
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
91
Minimum pKa ?
9
% buried
100
Peptide accession
P17735
Residue number A
151
Residue number B
275
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 151 of Tyrosine aminotransferase
Cysteine 275 of Tyrosine aminotransferase
3dyd B 353 B 431
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 353 and 431.
Details
Redox score ?
67
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
8
% buried
90
Peptide accession
P17735
Residue number A
353
Residue number B
431
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 353 of Tyrosine aminotransferase
Cysteine 431 of Tyrosine aminotransferase
3dyd B 404 B 431
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 404 and 431. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
90
Peptide accession
P17735
Residue number A
404
Residue number B
431
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 404 of Tyrosine aminotransferase
Cysteine 431 of Tyrosine aminotransferase
3dyd A 144 A 275
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 144 and 275. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
88
Minimum pKa ?
16
% buried
100
Peptide accession
P17735
Residue number A
144
Residue number B
275
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 144 of Tyrosine aminotransferase
Cysteine 275 of Tyrosine aminotransferase
3dyd A 151 A 211
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 151 and 211. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
P17735
Residue number A
151
Residue number B
211
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 151 of Tyrosine aminotransferase
Cysteine 211 of Tyrosine aminotransferase
3dyd B 144 B 151
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 144 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
100
Peptide accession
P17735
Residue number A
144
Residue number B
151
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 144 of Tyrosine aminotransferase
Cysteine 151 of Tyrosine aminotransferase
3dyd B 353 B 404
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 353 and 404. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
P17735
Residue number A
353
Residue number B
404
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 353 of Tyrosine aminotransferase
Cysteine 404 of Tyrosine aminotransferase
3dyd A 404 A 438
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 404 and 438. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
94
Peptide accession
P17735
Residue number A
404
Residue number B
438
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 404 of Tyrosine aminotransferase
Cysteine 438 of Tyrosine aminotransferase
3dyd A 211 A 275
A redox-regulated disulphide may form within Tyrosine aminotransferase between cysteines 211 and 275. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
3dyd
Structure name
human tyrosine aminotransferase
Structure deposition date
2008-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
P17735
Residue number A
211
Residue number B
275
Peptide name
Tyrosine aminotransferase
Ligandability
Cysteine 211 of Tyrosine aminotransferase
Cysteine 275 of Tyrosine aminotransferase
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