CTP synthase 1

A redox-regulated disulphide may form within CTP synthase 1 between cysteines 216 and 218. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

2vo1

Structure name

crystal structure of the synthetase domain of human ctp synthetase

Structure deposition date

2008-02-08

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

P17812

Residue number A

216

Residue number B

218

Peptide name

CTP synthase 1

Ligandability

Cysteine 216 of CTP synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of CTP synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CTP synthase 1 between cysteines 216 and 243. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7mip

Structure name

mouse ctps1 bound to inhibitor r80

Structure deposition date

2021-04-17

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

P70698

Residue number A

216

Residue number B

243

Peptide name

CTP synthase 1

Ligandability

Cysteine 216 of CTP synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 243 of CTP synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CTP synthase 1 between cysteines 216 and 234. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?