Vascular endothelial growth factor receptor 1
Intramolecular
Cysteine 252 and cysteine 311
Cysteine 158 and cysteine 207
Cysteine 53 and cysteine 107
Cysteine 454 and cysteine 535
Cysteine 577 and cysteine 636
Cysteine 912 and cysteine 1039
Cysteine 53 and cysteine 89
Cysteine 810 and cysteine 1018
Cysteine 89 and cysteine 107
5t89 Y 252 Y 311
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 252 and 311.
Details
Redox score ?
82
PDB code
5t89
Structure name
crystal structure of vegf-a in complex with vegfr-1 domains d1-6
Structure deposition date
2016-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17948
Residue number A
252
Residue number B
311
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 252 of Vascular endothelial growth factor receptor 1
Cysteine 311 of Vascular endothelial growth factor receptor 1
2xac C 158 C 207
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 158 and 207.
Details
Redox score ?
82
PDB code
2xac
Structure name
structural insights into the binding of vegf-b by vegfr-1d2: recognition and specificity
Structure deposition date
2010-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17948
Residue number A
158
Residue number B
207
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 158 of Vascular endothelial growth factor receptor 1
Cysteine 207 of Vascular endothelial growth factor receptor 1
5t89 Y 53 Y 107
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 53 and 107.
Details
Redox score ?
82
PDB code
5t89
Structure name
crystal structure of vegf-a in complex with vegfr-1 domains d1-6
Structure deposition date
2016-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17948
Residue number A
53
Residue number B
107
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 53 of Vascular endothelial growth factor receptor 1
Cysteine 107 of Vascular endothelial growth factor receptor 1
5t89 Y 454 Y 535
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 454 and 535.
Details
Redox score ?
79
PDB code
5t89
Structure name
crystal structure of vegf-a in complex with vegfr-1 domains d1-6
Structure deposition date
2016-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17948
Residue number A
454
Residue number B
535
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 454 of Vascular endothelial growth factor receptor 1
Cysteine 535 of Vascular endothelial growth factor receptor 1
5t89 Y 577 Y 636
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 577 and 636.
Details
Redox score ?
79
PDB code
5t89
Structure name
crystal structure of vegf-a in complex with vegfr-1 domains d1-6
Structure deposition date
2016-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17948
Residue number A
577
Residue number B
636
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 577 of Vascular endothelial growth factor receptor 1
Cysteine 636 of Vascular endothelial growth factor receptor 1
3hng A 912 A 1039
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 912 and 1039. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
3hng
Structure name
crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide
Structure deposition date
2009-05-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
94
Peptide accession
P17948
Residue number A
912
Residue number B
1039
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 912 of Vascular endothelial growth factor receptor 1
Cysteine 1039 of Vascular endothelial growth factor receptor 1
5t89 X 53 X 89
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 53 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5t89
Structure name
crystal structure of vegf-a in complex with vegfr-1 domains d1-6
Structure deposition date
2016-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
nan
Peptide accession
P17948
Residue number A
53
Residue number B
89
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 53 of Vascular endothelial growth factor receptor 1
Cysteine 89 of Vascular endothelial growth factor receptor 1
3hng A 810 A 1018
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 810 and 1018. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3hng
Structure name
crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide
Structure deposition date
2009-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
57
Peptide accession
P17948
Residue number A
810
Residue number B
1018
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 810 of Vascular endothelial growth factor receptor 1
Cysteine 1018 of Vascular endothelial growth factor receptor 1
5t89 X 89 X 107
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 1 between cysteines 89 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
5t89
Structure name
crystal structure of vegf-a in complex with vegfr-1 domains d1-6
Structure deposition date
2016-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
nan
Peptide accession
P17948
Residue number A
89
Residue number B
107
Peptide name
Vascular endothelial growth factor receptor 1
Ligandability
Cysteine 89 of Vascular endothelial growth factor receptor 1
Cysteine 107 of Vascular endothelial growth factor receptor 1
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