ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-complex protein 1 subunit alpha

Intramolecular
Cysteine 357 and cysteine 385
Cysteine 218 and cysteine 236
A redox-regulated disulphide may form within T-complex protein 1 subunit alpha between cysteines 357 and 385. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6nr9
Structure name
htric-hpfd class5
Structure deposition date
2019-01-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
67
Peptide accession
P17987
Residue number A
357
Residue number B
385
Peptide name
T-complex protein 1 subunit alpha

Ligandability

Cysteine 357 of T-complex protein 1 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of T-complex protein 1 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-complex protein 1 subunit alpha between cysteines 218 and 236. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6nr9
Structure name
htric-hpfd class5
Structure deposition date
2019-01-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
P17987
Residue number A
218
Residue number B
236
Peptide name
T-complex protein 1 subunit alpha

Ligandability

Cysteine 218 of T-complex protein 1 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of T-complex protein 1 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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