ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Early growth response protein 1

Intramolecular
Cysteine 396 and cysteine 399
Cysteine 368 and cysteine 371
Cysteine 340 and cysteine 345
A redox-regulated disulphide may form within Early growth response protein 1 between cysteines 396 and 399 (165 and 168 respectively in this structure).

Details

Redox score ?
90
PDB code
1a1f
Structure name
dsnr (zif268 variant) zinc finger-dna complex (gacc site)
Structure deposition date
1997-12-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
5
% buried
0
Peptide accession
P08046
Residue number A
396
Residue number B
399
Peptide name
Early growth response protein 1

Ligandability

Cysteine 396 of Early growth response protein 1

Cysteine 399 of Early growth response protein 1

A redox-regulated disulphide may form within Early growth response protein 1 between cysteines 368 and 371 (137 and 140 respectively in this structure).

Details

Redox score ?
90
PDB code
1a1l
Structure name
zif268 zinc finger-dna complex (gcac site)
Structure deposition date
1997-12-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
6
% buried
0
Peptide accession
P08046
Residue number A
368
Residue number B
371
Peptide name
Early growth response protein 1

Ligandability

Cysteine 368 of Early growth response protein 1

Cysteine 371 of Early growth response protein 1

A redox-regulated disulphide may form within Early growth response protein 1 between cysteines 340 and 345 (107 and 112 respectively in this structure).

Details

Redox score ?
88
PDB code
4x9j
Structure name
egr-1 with doubly methylated dna
Structure deposition date
2014-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
8
% buried
0
Peptide accession
P18146
Residue number A
340
Residue number B
345
Peptide name
Early growth response protein 1

Ligandability

Cysteine 340 of Early growth response protein 1

Cysteine 345 of Early growth response protein 1

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