ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gamma-aminobutyric acid receptor subunit gamma-2

Intramolecular
Cysteine 189 and cysteine 203
Cysteine 283 and cysteine 342
A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit gamma-2 between cysteines 189 and 203 (151 and 165 respectively in this structure).

Details

Redox score ?
84
PDB code
6dw0
Structure name
cryo-em structure of the benzodiazepine-sensitive alpha1beta1gamma2s tri-heteromeric gabaa receptor in complex with gaba (whole map)
Structure deposition date
2018-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18508
Residue number A
189
Residue number B
203
Peptide name
Gamma-aminobutyric acid receptor subunit gamma-2

Ligandability

Cysteine 189 of Gamma-aminobutyric acid receptor subunit gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of Gamma-aminobutyric acid receptor subunit gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit gamma-2 between cysteines 283 and 342 (244 and 303 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6x3w
Structure name
human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus phenobarbital
Structure deposition date
2020-05-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
98
Peptide accession
P18507
Residue number A
283
Residue number B
342
Peptide name
Gamma-aminobutyric acid receptor subunit gamma-2

Ligandability

Cysteine 283 of Gamma-aminobutyric acid receptor subunit gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Gamma-aminobutyric acid receptor subunit gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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