ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-1 receptor antagonist protein

Intramolecular
Cysteine 94 and cysteine 141
Cysteine 91 and cysteine 94
A redox-regulated disulphide may form within Interleukin-1 receptor antagonist protein between cysteines 94 and 141 (70 and 117 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1irp
Structure name
solution structure of human interleukin-1 receptor antagonist protein
Structure deposition date
1994-10-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
28
Peptide accession
P18510
Residue number A
94
Residue number B
141
Peptide name
Interleukin-1 receptor antagonist protein

Ligandability

Cysteine 94 of Interleukin-1 receptor antagonist protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Interleukin-1 receptor antagonist protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor antagonist protein between cysteines 91 and 94 (67 and 70 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
1irp
Structure name
solution structure of human interleukin-1 receptor antagonist protein
Structure deposition date
1994-10-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
60
Peptide accession
P18510
Residue number A
91
Residue number B
94
Peptide name
Interleukin-1 receptor antagonist protein

Ligandability

Cysteine 91 of Interleukin-1 receptor antagonist protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 94 of Interleukin-1 receptor antagonist protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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