ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Lymphocyte activation gene 3 protein

Intramolecular
Cysteine 369 and cysteine 412 L
Cysteine 282 and cysteine 333
Cysteine 189 and cysteine 241
Cysteine 44 and cysteine 160
A redox-regulated disulphide may form within Lymphocyte activation gene 3 protein between cysteines 369 and 412.

Details

Redox score ?
83
PDB code
7tzg
Structure name
structure of human lag3 in complex with antibody single-chain variable fragment
Structure deposition date
2022-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18627
Residue number A
369
Residue number B
412
Peptide name
Lymphocyte activation gene 3 protein

Ligandability

Cysteine 369 of Lymphocyte activation gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 412 of Lymphocyte activation gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lymphocyte activation gene 3 protein between cysteines 282 and 333.

Details

Redox score ?
82
PDB code
7tzh
Structure name
structure of human lag3 domains 3-4 in complex with antibody single chain-variable fragment
Structure deposition date
2022-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18627
Residue number A
282
Residue number B
333
Peptide name
Lymphocyte activation gene 3 protein

Ligandability

Cysteine 282 of Lymphocyte activation gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Lymphocyte activation gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lymphocyte activation gene 3 protein between cysteines 189 and 241.

Details

Redox score ?
82
PDB code
7tzg
Structure name
structure of human lag3 in complex with antibody single-chain variable fragment
Structure deposition date
2022-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P18627
Residue number A
189
Residue number B
241
Peptide name
Lymphocyte activation gene 3 protein

Ligandability

Cysteine 189 of Lymphocyte activation gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of Lymphocyte activation gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lymphocyte activation gene 3 protein between cysteines 44 and 160.

Details

Redox score ?
76
PDB code
7tzg
Structure name
structure of human lag3 in complex with antibody single-chain variable fragment
Structure deposition date
2022-02-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
8
Peptide accession
P18627
Residue number A
44
Residue number B
160
Peptide name
Lymphocyte activation gene 3 protein

Ligandability

Cysteine 44 of Lymphocyte activation gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of Lymphocyte activation gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: